Thermochemistry of aqueous solutions of alkylated nucleic acid bases. VIII. Enthalpies of hydration of 6-alkyluracils |
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| Authors: | W Zielenkiewicz A Zielenkiewicz K L Wierzchowski |
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| Affiliation: | (1) Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warszawa, Poland;(2) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Rakowiecka 36, 02-532 Warszawa, Poland |
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| Abstract: | Enthalpies of solution in water  H
sol
o
and enthalpies of sublimation H
sub
o
were determined for a number of crystalline derivatives of uracil: 1,6-dimethyluracil (m
2
1,6
Ura), 1,3,6-trimethyluracil (m
3
1,3,6
Ura), 6-ethyl-1,3-dimethyluracil (e6m
2
1,3
Ura), 6-propyl-1,3-dimethyluracil (pr6m
2
1,3
Ura) and 6-butyl-1,3-dimethyluracil (but6m
2
1,3
Ura). Standard enthalpies of hydration H
hydr
o
and standard enthalpies of interaction H
int
o
of the solutes with their hydration shells were calculated. The data obtained show that dependence of H
int
o
on the number of-CH2- groups of n-alkyl chain added upon substitution of diketopyrimidine ring is nonlinear. This finding is discussed in connection with results of X-ray diffraction structure determinations for the crystalline compounds. |
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| Keywords: | Enthalpy of solution enthalpy of sublimation enthalpy of hydration alkylated derivatives of uracil |
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