Pharmacokinetics of phenazone after bilateral ovariectomy in female rabbits] |
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Authors: | B Gawrońska-Szklarz A Kwiatkowski M Dro?dzik J Wójcicki |
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Affiliation: | Zak?adu Farmakologii Klinicznej PAM, Szczecinie. |
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Abstract: | The aim of this study was to evaluate the influence of female sex hormones on phenazone pharmacokinetics using as an experimental model female rabbits after a bilateral ovariectomy. Eighteen female rabbits divided into two groups: control animals and experimental rabbits, that underwent ovariectomy, were used in the study. Pharmacokinetic assays were performed in all animals: prior to the study, after 1 month and after 2 months. Blood was sampled within 24 hours after intragastric administration of phenazone at a dose 50 mg/kg b.w. Two compartment open model was used for calculations. Significant increase in AUC and prolongation of phenazone halflife as well as a decrease in the total body clearance were noted. The study demonstrated the possible inhibition of the microsomal mixed-function oxidase system by oestrogens. |
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