肿瘤转移相关基因与周围型肺癌CT征象的关系研究

摘要目的：探讨VEGF和nm23-H1基因表达水平与周围型肺癌的病理生理学特征和CT征象之间的关系。方法：回顾性分析确诊的47例周围型肺癌患者CT表现．同时采用免疫组化方法(LSAB法)检测47例肺癌组织中的VEGF和nm23-H1表达水平。结果：1)VEGF、nm23-H1表达水平与原发肿瘤大小、淋巴结转移状态，pTNM分期均有密切关系(P＜0．05)。2)VEGF与nm23-H1表达水平呈负相关(P＜0.05)。3)VEGF基因的高表达和nm23-H1基因的低表达均与分叶征、纵隔淋巴结转移有关(P＜0．05)，且VEGF的高表达也与空洞征有关：二者表达水平与毛刺征、空泡征、胸膜凹陷征和支气管征均无关(P＞0．05)。4)深分叶征、空泡征和支气管征与肿瘤大小有关(P＜0．05)，而与毛刺征、胸膜凹陷征和纵隔淋巴结转移均无关(P＞0.05)。结论：VEGF过度表达和nm23-H1低表达均与周围型肺癌的分叶征、空洞坏死征和纵隔淋巴结转移有密切关系。

The Study on the Relationship between the Related Genes of Tumor Metastasis and CT Signs of Lung Peripheral Cancer

Objective: To explore the relation between VEGF and nm23-H1 genes expression and the clinicopathological features and CT appearances in lung peripheral cancer. Methods: the CT findings of 47 cases patients with lung cancer were reviewed, and the VEGF,nm23-H1-H1 expression of lung peripheral cancer lesions were detected by immunohistochemistry(LSAB).Results: 1, The nm23-H1 and VEGF expression showed significant relation with the size of primary tumor, nodule metastasis, p-TNM stages of lung cancer (P<0.05). 2, The VEGF expression was negatively related to nm23-H1 in lung cancer (P<0.05); 3, The high expression of VEGF and the low expression of nm23-H1 were related to deep lobulation, metastasis of mediastinal lymph node (P<0.05), moreover VEGF expression showed relation to frank cavitation (P<0.05); though they showed no relation to spiculation sign,vacuole sign,pleural indentation sign and bronchus sign (P>0.05). 4, There exited a correlation between tumor size with deep lobulation, vacuole sign and bronchus sign (P<0.05), and no related to spiculation sign, pleural indentation sign and metastasis of mediastinal lymph node (P>0.05). Conclusion: Both VEGF overexpression and nm23-H1 low expression have a close relationship with the deep lobulation, metastasis of mediastinal lymph node and vacuole sign in lung peripheral cancer.