硒结合蛋白在膀胱癌中的表达及临床意义

目的 探讨硒结合蛋白-1(Selenium binding protein 1,SBP1)在不同膀胱组织中的表达情况及其临床意义.方法 运用Western blot法检测膀胱癌组织、膀胱黏膜良性病变组织及正常膀胱黏膜组织中的SBP1的表达,并分析其表达差异性.结果 SBP1在膀胱癌组织中的表达明显低于膀胱黏膜良性病变组织及正常膀胱黏膜(P＜0.05),且浅表性膀胱癌组织表达阳性率高于浸润性膀胱癌,无淋巴结转移的膀胱癌组织表达阳性率高于具有淋巴结转移的膀胱癌组织.结论 SBP1在膀胱癌组织中表达下调,膀胱癌的发生、进展可能与SBP1的表达抑制有关.

Expression and clinical role of Selenium binding protein 1 in bladder tumor

Objectives To investigate the expression of Selenium binding protein 1 (SBP1) in bladder tumor and its clinical significance.Methods 30 bladder cancer tissue and 20 bladder benign lesions and 8 bladder normal tissue were collected to detect the expression of SBP1 by Western blot.Results The expression of the SBP1 in bladder cancer tissue was down-regulated compared with that in bladder benign lesions and bladder normal tissue (0.325 ± 0.065vs0.578 ± 0.073vs0.749 ± 0.052), P ＜ 0.05, and the expression of SBP1 in the bladder neoplasms was higher than that in the invasive bladder cancer (0.548 ± 0.082vs0.361 ± 0.048), P ＜ 0.05.Moreover, the expression of SBP1 in lymphatic metastasis of bladder cancer was lower than that in no-lymphatic metastasis (0.241 ± 0.047vs0.409 ± 0.058), P ＜ 0.05.Conclusions SBP1 is down-regulated in bladder cancer and it is strongly related with the bladder progression, which means that it is probably play an important role in tumorigenesis.