麻痹性痴呆(附2例报告)

目的 探讨麻痹性痴呆（GPI）的临床表现、实验室检查、影像学改变和治疗。方法 回顾性分析2例GPI患者的临床资料结果2例患者均为男性，以记忆力下降和精神障碍为主要临床表现，1例出现内脏危象，血清及脑脊液快速血浆反应素环状卡片试验（RPR）、梅毒螺旋体明胶凝集试验（TPPA）均（＋），MRI检查均有脑室扩大经驱梅治疗后，2例患者病情均明显好转。结论 GPI多见于中年男性，误诊率高，对不明原因的年轻痴呆患者，应想到GPI的可能，及时诊断、积极治疗对其预后有重要意义。

General paralysis of insane: two case reports

Objective To explore the clinical manifestation,laboratory tests,imaging and treatment of general paralysis of insane(GPI).Methods The clinical data of 2 patients with GPI analyzed retrospectively.Results 2 sufferers were both male,and mainly presented with memory decline and mental disorder.One case presented with visceral crisis.Both rapid plasma reagin test and treponema gelatin agglutination test in serum and CSF were positive.Brain MRI scanning showed ventriculomegaly.After antisyphilitic treatments,2 patients obviously improved.Conclusion GPI are often seen in middle-aged males and its misdiagnosis rate is high.The diagnosis of GPI should be considered in young patients with dementia without clear reason.Early diagnosis and active treatments are important for the prognosis of this disease.