| 护肝解毒冲剂毒理学实验研究 |
| |
| 引用本文： | 黄爱平,李万平,顾立,刘剑.护肝解毒冲剂毒理学实验研究[J].泸州医学院学报,2005,28(6):493-496. |
| |
| 作者姓名： | 黄爱平 李万平 顾立 刘剑 |
| |
| 作者单位： | 泸州医学院药理学教研室,四川泸州,646000 |
| |
| 摘 要： | 目的:观察护肝解毒冲剂(HGCJ)对小鼠的急性毒性和对大鼠180天长期毒性.方法:采用小白鼠最大耐受量测定法和长期毒性试验进行研究.结果:HGCJ对小鼠灌胃给药的LD50＞200克(生药)/kg/次;大鼠长期毒性试验对动物一般行为活动、体重增长、外周血象、肝肾功能和病理组织学检查等与对照组比较未见显著性差异(P＞0.05).结论:HGCJ未见明显毒性,在临床长期用药是安全的.
|
| 关 键 词： | 护肝解毒 动物 试验 |
| 文章编号： | 1000-2669(2005)6-0493-04 |
| 收稿时间： | 03 22 2005 12:00AM |
| 修稿时间： | 2005年3月22日 |
TOXICOLOGICAL STUDY OF HUGAN JIEDU CHONGJI(HGCJ) |
| |
| Huang Aiping, et al.TOXICOLOGICAL STUDY OF HUGAN JIEDU CHONGJI(HGCJ)[J].Journal of Luzhou Medical College,2005,28(6):493-496. |
| |
| Authors: | Huang Aiping |
| |
| Affiliation: | Department of Pharmacology, Luzhou Medical College |
| |
| Abstract: | Objective: To observe the acute and long-term toxicity of HGCJ. Method: Maximum tolerence dose was determined on mice. Long-term (180 days) toxicity test was studied on rats. Results: LD_ 50 of HGCJ given orally, was more than 200g(crude drug)/kg, and there was no obvious long-term toxicity in general conditions, peripheral blood picture, function of liver and kidney, and pathological histology in rats. Conclusion: No evident toxicity was found. Its clinical use is safe. |
| |
| Keywords: | Hugan jiedu chongji Animals Experiments |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
