龙须草水煎液对糖尿病大鼠血糖和胰岛素水平的影响

目的:探讨龙须草水煎液对糖尿病大鼠血糖和胰岛素水平的影响.方法:大鼠以高脂饲料喂养1个月诱导加1次性ip链脲佐菌素制造2型糖尿病模型,将Wistar雄性大鼠随机分成6组:正常对照组、模型组、二甲双胍(0.15 g·kg-1·d-1),龙须草水煎液低、中、高剂量组(2.5,5,10 g·kg-1·d-1),口服给药30 d,并在相应时间采血测定空腹血糖(FBG)、糖耐量2h血糖、空腹胰岛素(FINS).结果:龙须草水煎液中、高剂量给药30 d糖尿病大鼠FBG分别为(14.30 ±3.04),(13.25±3.81)mmol·L-1低于模型组(P＜0.01)；大鼠糖耐量分别为(13.44 ±3.24),(13.03±4.72) mmol·L-1低于模型组(P＜0.05)；血清胰岛素水平分别为(15.40±3.76),(16.39±4.75)mU·L-1高于模型组(P＜0.01).结论:龙须草水煎液对高血糖模型大鼠具降低血糖和升高胰岛素水平的作用.

Effects of Juncus setchuensis Decoction on FBG and FINS Levels in Diabetes Rats

Objective: To investigate effects of Juncus setchuensis decoction on the fasting blood glucose(FBG)and the fasting insulin levels(FINS) in rats. Method: The type 2 diabetes models in rats were made by fedding high lipids foods for one month together with injecting the streptozotocin(STZ)of small dose one time. The rats were randomly divided into 6 groups: control group,model group,metformin group (0.15 mg·kg^-1·d^-1 ),Low, medium, and high dose groups of J. setchuensis decoction(2.5,5,10 g·kg^-1·d^-1). The contents of fasting blood glucose( FBG),oral glucose tolerance test (OGTT) and fasting insulin( FINS) were determined. Result: FBG of diabetic rats which were fed with J. setchuensis decoction of medium and high dose respectively were (14.30±3.04),(13.25±3.81)mmol·L^-1,and glucose tolerance respectively were(13.44±3.24),(13.03±4.72)mmol·L^-1,and serum insulin levels were( 15.40±3.76),(16.39±4.75)mU·L^-1.It showed that the J. setchuensis decoction in high dose and medium dose had significant effect of decreasing FBG and increasing FINS indiabetic rats. Conclusion: J. setchuensis decoction could decrease FBG and increase FINS levels in diabetic rats.