藤甲酰苷缓释片的制备及体外释药因素考察

目的制备藤甲酰苷缓释片并研究其体外药物释放行为。方法通过亲水凝胶骨架型缓释技术,以羟丙基甲基纤维素(HPMC)为缓释材料、乙基纤维素(EC)为凝胶骨架材料制备藤甲酰苷缓释片;考查了释放介质的pH值、骨架材料与其用量、致孔剂的类型与用量、压片压力等工艺因素和条件对藤甲酰苷缓释片体外药物释放行为的影响。结果药物的释药速率受骨架材料的规格和用量、致孔剂种类的影响;释放介质pH值、转速和压片压力对释药速率有一定影响。结论研制的藤甲酰苷缓释片处方合理,有较好的可控性和重现性。

Preparation and in vitro release of Garcinia glycosides sustained-release tablets

Objective To prepare Garcinia glycosides sustained-release tables and study their in vitro release characteristics.Methods Garcinia glycosides sustained-release tablets were prepared by hydroxypropylmethyl cellulose(HPMC) as gel matrix material and ethyl cellulose(EC) as skeleton material.Factors influencing the release rate of Garcinia glycosides from the sustained-release tablets,such as pH of release medium,skeleton material and amount of HPMC,porogen of type and amount,and tabletting pressure,were studied.Results Garcinia glycosides release rate was controlled obviously by the specifications and amount of skeleton material and porogen type.While the influence of pH,speed and tabletting pressure had certain influences to the release rate.Conclusion The selected formulation of Garcinia glycosides sustained-release tablets was reasonable with good controllability and reproducibility.