First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain |
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Authors: | Pitart Cristina Solé Mar Roca Ignasi Fàbrega Anna Vila Jordi Marco Francesc |
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Affiliation: | Department of Clinical Microbiology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain. cristinapitart@gmail.com |
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Abstract: | Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 β-lactamase. A conjugative plasmid of circa 70 kb carrying bla(OXA-48) was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain. |
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