| 混合药膜缓释体系动力学模型 |
| |
| 引用本文： | 徐铜文,王绍亭.混合药膜缓释体系动力学模型[J].化工学报,1995,46(5):593-600. |
| |
| 作者姓名： | 徐铜文 王绍亭 |
| |
| 作者单位： | 天津大学化工系!天津300072,天津大学化工系!天津300072 |
| |
| 摘 要： | 将化学工程原理应用于药物控制释放建立了应用范围较广的混合药膜缓释体系的动力学模型,讨论了混合药膜的内扩散过程,针对氟尿嘧啶(5-FU)和乙烯-乙烯醇共聚物(EVAL)组成的混合药膜体系进行了实验验证。结果表明本文模型与实验符合良好,并能为Higuchi模型的假设提供理论依据。
|
| 关 键 词： | 混合药膜 控制释放 动力学模型 缓释体系 药物 |
KINETIC MODELS OF CONTROLLED RELEASE FOR MONOLITHIC MATRIX SYSTEM |
| |
| Xu Tongwen and |Wang Shaoting.KINETIC MODELS OF CONTROLLED RELEASE FOR MONOLITHIC MATRIX SYSTEM[J].Journal of Chemical Industry and Engineering(China),1995,46(5):593-600. |
| |
| Authors: | Xu Tongwen and |Wang Shaoting |
| |
| Abstract: | This paper deals with controlled release of drug based on the principle of chemical engineering. The comprehensive kinetic models for monolithic matrix are derived and the internal diffusional process is discussed. The models are tested by the polyCethylene -vinyl al-cohol)/5 - Fluorouracilum(EVAL/5 -FU)matrix system. The results show that the models, which can theoretically support the hypotheses of Higuchi's model, agree well with experimental data. |
| |
| Keywords: | monolithic matrix controlled release kinetic models poly(ethylene -vinyl alco-hol)(EVAL) 5 - Fluorouracilum(5 - FU) |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《化工学报》浏览原始摘要信息 |
|
点击此处可从《化工学报》下载全文 |
