颅脑损伤手术患者超敏C反应蛋白与病情进展及预后的关系

目的探讨颅脑损伤手术患者脑脊液超敏C反应蛋白(hs-CRP)与脑损伤类型、病情进展及预后的关系。方法颅脑损伤手术患者60例,按颅脑损伤分型及手术方式分为3组,Ⅰ组:单侧硬膜外血肿开颅手术组23例;Ⅱ组:单侧硬膜下血肿开颅手术组22例;Ⅲ组:广泛性脑挫裂伤开颅组15例。采集颅脑损伤患者术中至术后3周的脑脊液,以散射免疫比浊法测定脑脊液hs-CRP的含量,分析其预测各组预后的效果,并与相应影像学资料进行比较。结果术后10d3组脑脊液hs-CRP含量比较差异有统计学意义(P0.01);hs-CRP含量与脑损伤类型密切相关并可预测颅脑损伤手术患者的预后,hs-CRP的变化与影像学改变亦密切相关。结论脑脊液hs-CRP的含量与不同脑损伤类型、预后密切相关,对判断病情变化有重要意义。

Correlation of high sensitivity C-reactive protein with progression and prognosis of postoperative patients

Objective To explore the relationship of high sensitivity C-reactive protein(hs-CRP)in cerebrospinal fluid with the type of brain injury,progression and prognosis of postoperative patients.Methods According to the type of brain injury and surgical procedure,60 surgical patients were divided into three groups,23 surgical patients with epidural hematoma in group Ⅰ,22 surgical patients with subdural hematoma in groupⅡ,15 surgical patients with extensive contusion and laceration in groupⅢ.The cerebrospinal fluid were collected from the surgical patients during the period of one day and three weeks.Immunoturbidimetric as-say was used to detect the level of hs-CRP in cerebrospinal fluid which was compared with the real-time imaging data.Results The differences of hs-CRP were significantly statistically between different groups at the same point time.The value of hs-CRP correlated with CT characteristics and suggested the disease trend earlier.Conclusion The value of hs-CRP in cerebrospinal fluid is closely related to different types of brain injury and prognosis,which is a sensitive marker for surgical patients.