我院1283例外科Ⅰ类切口手术围术期抗菌药物预防应用分析

目的:了解我院Ⅰ类切口手术围术期预防应用抗菌药物情况和合理性,为持续改进抗菌药物专项整治活动方案提供科学的参考依据。方法:采用等间隔抽样方法抽取我院2012年10月-2013年9月出院患者中的Ⅰ类切口手术病例1 283例,对Ⅰ类切口手术患者围术期预防应用抗菌药物进行回顾性分析。结果:在1 283例Ⅰ类切口手术中,围术期预防性应用抗菌药物401例,总预防应用率为31.25%;预防用抗菌药物以头孢唑林为主,共180例(占44.89%),其次为头孢呋辛155例(占38.65%);选药超出相关管理规定者62例(占15.46%),预防用药时间超过48 h者148例(占36.91%),单次给药剂量偏大者23例(占5.74%),预防用药时机不适宜者1例(占2.50%)。结论:Ⅰ类切口手术预防应用抗菌药物不合理现象依然存在,医院必须加强抗菌药物临床应用的管理,持续改进抗菌药物专项整治活动的力度,促进抗菌药物临床的合理应用。

Analysis of Perioperative Prophylactic Application of Antibiotics in 1 283 Cases of Type I Incision Operation in Our Hospital

OBJECTIVE： To investigate the perioperative prophylactic application of antibiotics n type I incision operation in our hospital retrospectively, and to provide scientific reference for special rectification activities of antibiotics. METHODS： Retrospective analysis was performed to investigate perioperative prophylactic application of antibiotics in 1 283 discharged pa- tients underwent type I incision surgery from Oct. 2012 to Sept. 2013 in our hospital. RESULTS： Of 1 283 cases, there were 401 cases of perioperative prophylactic application of antibiotics with application rate of 31.25%. Cefazolin as main prevention drugs was used in 180 cases （44.89%）, followed by 155 cases of cefuroxime （38.65%）. 62 cases were beyond the related man- agement regulation in drug selection （15.46%）. Medication time of 148 patients was more than 48 h （36.91%）. 23 cases were given single large doses （5.74%）. The medication timing of 1 case was not rational （2.50%）. CONCLUSIONS： There is still ir- rational prophylactic application of antibiotics for type I incision operation; it is necessary to further strengthen the management of antibiotics use, continuously promote special rectification activities of antibiotics in order to improve the rational use of antibiotics in the clinic.