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The Catalytic Asymmetric α‐Benzylation of Aldehydes |
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| Authors: | Prof. Dr. Benjamin List Dr. Ilija Čorić Dr. Oleksandr O. Grygorenko Philip S. J. Kaib Prof. Dr. Igor Komarov Dr. Anna Lee Markus Leutzsch Dr. Subhas Chandra Pan Andrey V. Tymtsunik Manuel van Gemmeren |
| Affiliation: | 1. Max‐Planck‐Institut für Kohlenforschung, Kaiser Wilhelm‐Platz 1, 45470 Mülheim an der Ruhr (Germany);2. Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv (Ukraine) |
| Abstract: | The first aminocatalyzed α‐alkylation of α‐branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α‐branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α‐alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities. |
| Keywords: | α ‐alkylation α ‐branched aldehydes DYKATt enamine catalysis organocatalysis |
