非小细胞肺癌雌激素受体表达与性别关系的Meta分析

目的:评估非小细胞肺癌（non-small cell lung cancer，NSCLC）中雌激素受体（estrogen receptor，ER）表达与性别的关系。方法:通过计算机检索PubMed、EMBASE、Cochrane Library数据库，检索截止日期为2018年3月。纳入符合标准的文献，使用stata 12.0软件计算非小细胞肺癌中雌激素受体表达与性别关系的相对危险度（relative ratio，RR）。结果:共有10篇研究被提取出来，包含1 557例非小细胞肺癌患者，其中女性患者525例，男性患者1 032例。非小细胞肺癌中女性患者的雌激素受体表达阳性率明显高于男性患者［RR=1.15，95%CI（1.06~1.24），P=0.001］，敏感性分析发现本研究的合并结果基本可靠，Egger检验、Begg检验提示本研究不存在发表偏倚。结论:雌激素受体阳性可能使女性更容易患非小细胞肺癌，导致女性肺癌发病率增高。

Meta analysis of the association between estrogen receptor expression and gender in non-small cell lung cancer

Objective:To evaluate the association between estrogen receptor (ER) expression and gender in non-small cell lung cancer (NSCLC).Methods:The PubMed，EMBASE，and Cochrane Library databases were searched by computer and the search deadline was March 2018.The standards-compliant literature was included and the relative ratio (RR) of the association between estrogen receptor expression and gender in non-small cell lung cancer was calculated using stata 12.0 software.Results:A total of 10 studies were extracted，including 1 557 patients with NSCLC，including 525 female patients and 1 032 male patients.The positive rate of estrogen receptor expression in female patients with non-small cell lung cancer was significantly higher than that of male patients
［RR=1.15，95%CI (1.06 to 1.24)，P=0.001］.Sensitivity analysis found that the combined results were basically reliable.The Egger test and Begg test indicated that there was no publication bias in this study.Conclusion:Estrogen receptor positive may make women more susceptible to non-small cell lung cancer，leading to a sharp increase in the incidence of female lung cancer.