| 高血糖和蛋白尿促进肾小管上皮细胞凋亡 |
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| 引用本文： | 桂华珍,阎秀英,肖瑛,石明隽,张国忠. 高血糖和蛋白尿促进肾小管上皮细胞凋亡[J]. 贵阳医学院学报, 2011, 36(5): 448-451 |
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| 作者姓名： | 桂华珍 阎秀英 肖瑛 石明隽 张国忠 |
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| 作者单位： | 1. 贵阳医学院机能学实验室,贵州贵阳,550004
2. 贵阳医学院病理生理学教研室,贵州贵阳,550004 |
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| 基金项目： | 高等学校博士学科点基金[20060660001]; 贵州省科技计划课题[黔科合SY字(2008)3042] |
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| 摘 要： | 目的:探讨糖尿病(DM)病程中高血糖和蛋白尿与肾小管上皮细胞凋亡的关系.方法:SD大鼠随机分为对照组和糖尿病组,注射链脲佐菌素(STZ)诱导糖尿病,分别于糖尿病2周、4周、8周、16周和24周处死动物;检测血糖和24 h尿蛋白量,免疫组织化学检测Bcl-2和Bax蛋白表达,TUNEL法检测细胞凋亡.结果:与对照组相比,...
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| 关 键 词： | 高血糖症 蛋白尿 肾小管 细胞凋亡 免疫组织化学 大鼠,Sprague-Dawley |
Hyperglycemia and Proteinuria Promote Apoptosis of Renal Tubular Epithelial Cells |
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| GUI Huazhen,YAN Xiuying,XIAO Ying,SHI Mingjun,ZHANG Guozhong. Hyperglycemia and Proteinuria Promote Apoptosis of Renal Tubular Epithelial Cells[J]. Journal of Guiyang Medical College, 2011, 36(5): 448-451 |
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| Authors: | GUI Huazhen YAN Xiuying XIAO Ying SHI Mingjun ZHANG Guozhong |
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| Affiliation: | GUI Huazhen1,YAN Xiuying2,XIAO Ying2,SHI Mingjun2,ZHANG Guozhong2 (1.Department of Function Laboratory,Guiyang Medical College,Guiyang 550004,Guizhou,China,2.Department of Pathophysiology,China) |
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| Abstract: | Objective: To explore the relation of hyperglycemia and proteinuria to apoptosis of renal tubular epithelial cells in the diabetic course.Methods: Sprague-Dawley rats were randomly divided into control group and diabetic group.Diabetic models were established by injection with streptozotocin(STZ).Rats were sacrificed in 2,4,8,16 and 24 weeks(groups DM2w,DM4w DM8w DM16w and DM24w) respectively.Blood glucose and 24h urine protein were examined with biochemistry method.Immunochemistry was employed to detect th... |
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| Keywords: | hyperglycemia proteinuria kidney tubules apoptosis immunohistochemistry rats Sprague-Dawley |
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