新生儿社区获得性肺炎病原微生物分布及药敏分析

目的 了解新生儿社区获得性肺炎病原微生物分布及药敏状况.方法 收集124例新生儿社区获得性肺炎患儿,取痰样本检测病原菌和药敏试验.结果 124例样本共检出病原微生物143株,G-菌以大肠埃希菌占比最高,G＋菌以金黄色葡萄球菌占比最高,病毒以呼吸道合胞病毒占比最高.本组主要G-菌大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌对阿米卡星的敏感率均为100％.本组主要G＋菌金黄色葡萄球菌、表皮葡萄球菌对利奈唑胺的敏感率均为100％.早产儿混合感染和病毒感染率均显著高于足月儿,G-菌感染率则显著低于足月儿,低体重儿混合感染和病毒感染率均显著高于正常体重儿,早期新生儿混合感染率显著高于晚期新生儿（P均＜0.05）.结论 本地区新生儿社区获得性肺炎病原菌以G-菌为主,主要G-菌对阿米卡星敏感性高,主要G＋菌对利奈唑胺的敏感性高,早产、低体重和出生早期的混合感染发生率高,增加治疗难度.

Analysis of neonatal community-acquired pneumonia pathogen distribution and drug sensitivity

Objective To understand neonatal community-acquired pneumonia pathogen distribution and drug suscepti- bility status. Methods Treated 124 cases of neonatal community-acquired pneumonia, take sputum samples tested pathogens and drug susceptibility tested. Results The 124 cases were detected in samples of 143 pathogenic microor- ganisms.The major group G-bacteria Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae sensitive to amikacin rate was 100%.The major group G~ bacteria Staphylococcus aureus,Staphylococcus epidermidis sensitive to linezolid were 100%. Premature children mixed infections and viral infection rates were significantly higher than full-term chil- dren, G- bacteria infection rate was significantly lower than full-term children,low birth weight children of mixed infec- tion and viral infection rates were significantly higher than normal weight children ,early neonatal mixed late neonatal infection rate was significantly higher（P〈0.05 ）. Conclusion The regional neonatal community-acquired pneumonia pathogens G-bacteria,mainly G-bacteria highly sensitive to amikacin,mainly G~ bacteria to linezolid high sensitivity, premature birth,low birth weight and early is a high incidence of mixed infections,increasing the difficuhy of treatment.