| 芍药甙在兔和大鼠体内的药动学研究 |
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| 引用本文： | 陈光亮,陈崇宏.芍药甙在兔和大鼠体内的药动学研究[J].中国药理学通报,1992,8(4):278-280,285. |
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| 作者姓名： | 陈光亮 陈崇宏 |
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| 作者单位： | 安徽中医学院药理教研室 230038
(陈光亮)，安徽医科大学临床药理研究所 合肥230032
(陈崇宏)，安徽医科大学临床药理研究所 合肥230032(徐叔云) |
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| 摘 要： | 兔iv25mg·kg~(-1)芍药甙后,血药浓度—时间曲线符合二室模型。药动学参数为T_(1/2α)=5.93min,T_(1/2β)66.02min,V(?)=516.8ml·kg~(-1),CL=6.11ml·kg~(-1)·min~(-1)。兔ig250mg·kg~(-1)芍药甙,生物利用度为F=7.24％±4.15％,T_(max)=77.4min,C_(max)=21.57mg·L~(-1)大鼠ig550mg·kg~(-1)芍药甙,24h内粪、尿排泄量及iv55mg·kg~(-1)7h内胆汁排泄量分别占给药量的10.61％、1.08％、864％。离体肝脏灌流结果提示:芍药甙在肝内代谢少.
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| 关 键 词： | 芍药甙 高效液相色谱法 药代动力学 生物利用度 肝脏灌流 药物代谢 |
The studies on pharmacokinetics of paeoniflorin in rabbits and rats |
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| CHEN Guang -Liang. CHEN Chong -Hong,XU Shu -Yu.The studies on pharmacokinetics of paeoniflorin in rabbits and rats[J].Chinese Pharmacological Bulletin,1992,8(4):278-280,285. |
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| Authors: | CHEN Guang -Liang CHEN Chong -Hong XU Shu -Yu |
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| Abstract: | After iv 25mg · kg-1 paeoniflorin (PF)in rabbits, the concentration-time curves of the PF were shown to fit an two compartment model. The pharmacokinetic parameters were as follows; T1/2α = 5. 93 min. T1/2β = 66. 02 min. Vb = 5l6. 8 ml · kg-1, CL=6. I I ml · kg-1 · min. The bioavail-
ability of PF after ig 250mg · kg-1 in rabbits was F=7. 24 ± 4. 15%. Tmax=77. 42 min. Cmax = 21. 57mg · L-1. After ig 550mg · kg-1 PF. about 10. 6 1 % . 1. 08% of the dose was recovered from the rat feccs. urine respectively within 24h. After iv 55mg · kg-1 PF.about 8. 64% of the dose was recovered from the rat bile within 7h. The metabolism of PF was studied in isolated perfused rat liver, the PF concentrations in Krebs -Henseleit solution had little changed during 90 min by recirculating per-fusion. |
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| Keywords: | Paeoniflorin HPLC Pharmacokinetics Bioavailability Isolated perfused liver Drug metabolism |
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