| 四逆散冻干粉中的柴胡皂苷C对小鼠睡眠影响的实验研究 |
| |
| 引用本文： | 李越峰,严兴科,李廷利.四逆散冻干粉中的柴胡皂苷C对小鼠睡眠影响的实验研究[J].中国临床药理学杂志,2011,27(8). |
| |
| 作者姓名： | 李越峰 严兴科 李廷利 |
| |
| 作者单位： | 1. 甘肃中医学院,兰州,730000
2. 黑龙江中医药大学,哈尔滨,150040 |
| |
| 基金项目： | 国家自然科学基金资助项目(30672634); 甘肃省自然科学基金资助项目(1010RJZA212); 2010年甘肃医学院引进人才科研启动基金资助项目 |
| |
| 摘 要： | 目的研究四逆散冻干粉中主要成分柴胡皂苷C对小鼠睡眠的影响。方法将小鼠随机分成3组:空白对照组、模型组和给药组,四逆散冻干粉中有效成分柴胡皂苷C 12 g.kg-1经灌胃给予给药组;空白对照组、模型组均给予同体积的蒸馏水。于末次给药前8 h禁食,给药60 min后,腹腔注射50 mg.kg-1戊巴比妥钠,观察并记录翻正反射消失至恢复时间,即睡眠时间。结果柴胡皂苷C可明显延长戊巴比妥钠所致小鼠睡眠时间,与空白组比较具有极显著性差异(P<0.01)。结论四逆散冻干粉中有效成分柴胡皂苷C可延长阈剂量戊巴比妥钠所致小鼠睡眠时间,效果明显。
|
| 关 键 词： | 四逆散冻干粉 柴胡皂苷C 睡眠时间 |
Experimental study on the effects of Saikosaponin C in freeze-dry powder of Si-Ni-San on sleep time in mice |
| |
| LI Yue-feng,YAN Xing-ke,LI Ting-li.Experimental study on the effects of Saikosaponin C in freeze-dry powder of Si-Ni-San on sleep time in mice[J].The Chinese Journal of Clinical Pharmacology,2011,27(8). |
| |
| Authors: | LI Yue-feng YAN Xing-ke LI Ting-li |
| |
| Affiliation: | LI Yue-feng1,YAN Xing-ke1,LI Ting-li2(1.University of Traditional Chinese Medicine(TCM) of Gansu,Lanzhou 730000,China,2.University of TCM of Heilongjiang,Haerbin 150040,China) |
| |
| Abstract: | Objective To study on the effects of Saikosaponin C in freeze-dry powder of Si-Ni-San on sleep time in mice.Methods Effects of Saikosaponin C in freeze-dry powder of Si-Ni-San on the prolonged the sleep time in mice induced by sodium pentobarbital was observed.Results There was significantly prolonged the sleep time of Saikosaponin C in mice.Conclusion Saikosaponin C in freeze-dry powder of Si-Ni-San had hypnotic efficacy on the sleep time in mice induced by pentobarbital sodium. |
| |
| Keywords: | freeze-dry powder of Si-Ni-San Saikosaponin C sle ep time |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
