血清CA125与慢性心力衰竭严重程度及近期预后相关性分析

目的 探究血清CA125对慢性心力衰竭严重程度及与近期预后相关性.方法 通过对我院2012年3月至2015年5月心血管内科就诊收治的72例慢性心力衰竭患者做回顾性分析,并根据心功能分级分为慢性心衰Ⅰ~Ⅱ级组,慢性心衰Ⅲ组,慢性心衰Ⅳ组(各24例),比较各组患者CA125、NT-proBNP表达水平及LVEF指数,并分析其与近期预后相关性.结果 CHF各组CA125、NT-proBNP的表达水平均明显高于健康组,LVEF水平低于健康组(P<0.05),且慢性心衰Ⅲ、Ⅳ级组CA125、NT-proBNP的表达水平明显高于慢性心衰Ⅰ~Ⅱ级组,LVEF水平低于慢性心衰Ⅰ~Ⅱ级组(P<0.05),慢性心衰Ⅳ级组CA125、NT-proBNP的表达水平明显高于慢性心衰Ⅲ组,且LVEF水平低于慢性心衰Ⅲ组(P<0.05);CHF组患者血清CA125水平与NT-proBNP呈正相关(rs=0.548,P=0.012),与LVEF呈负相关(rs=-0.515,P=0.021);单因素分析:CA125、NT-proBNP、LVEF指标水平在终点事件发生组和未发生组间存在差异(P<0.05);多因素分析:高血清CA125、高血清NT-proBNP、低LVEF水平是影响终点事件发生的独立危险因素.结论 CA125在CHF患者中存在高表达,随着CHF病变严重程度增加而升高,和NT-proBNP指标呈正相关关系,和LVEF指标呈负相关关系,且血清高浓度CA125是影响终点事件发生的危险独立因素,故其可能作为临床CHF患者近期预后情况的评判指标.

Correlation Between Peripheral Serum CA125 Level and Severity and Short-term Prognosis of Patients with Chronic Heart Failure

Objective To investigate the correlation between peripheral serum CA125 level and severity and short-term prognosis of patients with chronic heart failure.Methods 72 cases with chronic heart failure in our hospital from March 2012 to May 2015 were retrospectively analyzed, and according to the cardiac function classification, cases were divided into chronic heart failure I-II group, chronic heart failure III group, chronic heart failure IV group (24 cases each group).The levels of CA125, NT-proBNP were evaluated in each group.The testing LVEF index and their correlation with prognosis were analyzed.Results:The levels of CA125 and NT-proBNP in CHF patients were significantly higher than that of the healthy group and the LVEF level less than healthy group (P<0.05).The levels of CA125 and NT-proBNP in the chronic heart failure Ⅲ or Ⅳ group were significantly higher than that of chronic heart failure I-II group and the LVEF level was lower than that in the chronic heart failure I-II group (P<0.05).The level of CA125, NT-proBNP in the chronic heart failureⅣ group were significantly higher and the level of LVEF lower than that of the chronic heart failure Ⅲ group (P<0.05).In these observations, the serum CA125 level showed significant positive correlation with NT-proBNP in CHF patients (rs=0.548, P=0.012) and negatively related to the LVEF (rs=-0.515, P=0.021);Single factor analysis showed that the levels of CA125, NT-proBNP, LVEF were no differences between event group and non-event group(P<0.05).Multivariate analysis showed that high serum CA125, high serum NT-proBNP, low LVEF level were independent risk factors for end point events.Conclusion The level of CA125 in patients with CHF is high and the levels increased as the severity of CHF increased.It was positively correlated with NT-proBNP index and negatively correlated with LVEF.Serum CA125 of high concentration is a risk factor influencing the endpoint events, which could be used as evaluation index of the recent prognosis of clinical CHF patients.