葛根黄酮抗心律失常作用

本实验比较了黄豆甙元、葛根素和葛根乙醇提取物对实验性心律失常的对抗作用。结果表明:静脉注射或灌服葛根素能明显对抗乌头碱和氯化钡引起的大鼠心律失常。灌服相应克分子的黄豆甙元或葛根乙醇提取物也能明显对抗以上两种心律失常,并能预防氯化钙所致的大鼠室颤和氯仿所致的小鼠室颤。连续灌服黄豆甙元能减少结扎大鼠冠脉后所致的心室纤颤发作时间。静注葛根素还能明显延长在体猫心的动作电位时程和有效不应期,反映有降低心肌兴奋性的作用。

THE ANTIDYSRHYTHMIC EFFECT OF PUERARIAE ISOFLAVONES

In anesthetized rats, arrhythmia induced by aconitine and BaCl_2 was shown to be antagonized by intravenously or orally administered puerarin, the main constituent of puerariae isoflavones. These two types of arrhythmia were also attenuated after oral administration of daidzein, the basic structure of puerariae isoflavones, and by equivalent doses of the alcoholic extract of puerariae which contains 40% of total isoflavones. Furthermore, ventricular fibrillation induced by CaCl_2 in rats and by chloroform in mice was prevented by daidzein or the alcohol extract of puerariae given orally. The duration of the ventricular fibrillation produced by occlusion of the coronary artery in rats was significantly decreased by daidzein given orally for 4 days. In anesthetized cats, the duration of monophasic action potentials and the effective refractory period of heart in situ were prolonged significantly by intravenous injection of puerarin. These results indicate that puerariae isoflavones can decrease myocardial excitability and may be beneficial in the treatment of myocardial ischemia.