Synthesis and Crystal Structure Studies of a Novel Bioactive Heterocycle: 1-Benzhydryl-4-phenylmethane Sulfonyl Piperazine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis and Crystal Structure Studies of a Novel Bioactive Heterocycle: 1-Benzhydryl-4-phenylmethane Sulfonyl Piperazine

Authors:	C. S. Ananda Kumar S. Naveen S. B. Benaka Prasad N. R. Thimme Gowda N. S. Linge Gowda M. A. Sridhar J. Shashidhara Prasad K. S. Rangappa

Affiliation:	(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India;(2) Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore, 570 006, India

Abstract:	1-Benzhydryl-4-phenylmethane sulfonyl piperazine was synthesized from 1-benzhydryl piperazine with phenylmethane sulfonyl chloride. The product obtained was characterized by ¹H NMR, MS and IR techniques and finally confirmed by X-ray crystallography. The title compound C₂₄H₂₆N₂O₂S, M _r = 406.53, crystallizes in the orthorhombic crystal class in the space group Pbca with unit cell parameters a = 11.1240(10)Å, b = 9.4940(15)Å, c = 40.239(4)Å, Z = 8 and V = 4249.7(9)Å³. The structure was solved by direct methods and refined to R ₁=0.0561 for 2,445 reflections with [I > 2 σ(I)]. The piperazine ring adopts a chair conformation. The sulfonyl moiety is in a distorted tetrahedral configuration.

Keywords:	Benzhydrylpiperazine Sulfonyl chloride Crystal structure Tetrahedral configuration
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