| 4-(2-溴乙酰基)-3-氟苯硼酸的制备 |
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| 引用本文： | 蒋辉,刘早霞,张永飞. 4-(2-溴乙酰基)-3-氟苯硼酸的制备[J]. 中国医药工业杂志, 2005, 36(9): 533-534 |
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| 作者姓名： | 蒋辉 刘早霞 张永飞 |
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| 作者单位： | 浙江普洛康裕药业有限公司,浙江,东阳,322118 |
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| 摘 要： | 4-溴-2-氟苯基氰经格氏反应得到4-溴-2-氟苯乙酮,先保护羰基,再经格氏反应和二羟硼基取代、溴代制得4-(2-溴乙酰基)-3-氟苯硼酸,总收率54%.
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| 关 键 词： | 4-(2-溴乙酰基)-3-氟苯硼酸 中间体 合成 |
| 文章编号： | 1001-8255（2005）09-0533-02 |
| 收稿时间： | 2005-07-20 |
| 修稿时间： | 2005-07-20 |
Preparation of 4- (2-Bromoacetyl) -3-fluorophenylboronic Acid |
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| JIANG Hui,LIU Zao-xia,ZHANG Yong-Fei. Preparation of 4- (2-Bromoacetyl) -3-fluorophenylboronic Acid[J]. , 2005, 36(9): 533-534 |
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| Authors: | JIANG Hui LIU Zao-xia ZHANG Yong-Fei |
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| Abstract: | 4-(2-Bromoacetyl)-3-fluorophenylboronic acid was synthesized from 4-bromo-2-fluorobenzonitrile b Grignard reaction, protection of carbonyl with ethanediol, Grignard reaction and substitution by borono group to give 4 acetyl-3-fluorophenylboric acid followed by bromination with an overall yield of 54%. |
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| Keywords: | 4-(2-bromoacetyl)-3-fluorophenylboronic acid intermediate synthesis |
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