尼莫地平联合银杏叶片治疗血管性痴呆疗效观察

目的:观察尼莫地平联合银杏叶片治疗血管性痴呆(VD)的临床疗效。方法:将83例VD患者随机分成对照组41例和联合组42例,2组均给予常规治疗,联合组同时口服尼莫地平及银杏叶片。应用修订简易精神状态量表(MMSE)和日常生活能力(ADL)量表评价疗效,比较治疗前后患者平均脑血流量(mCBF)。结果:对照组治疗前后各项评分无差异;联合组治疗后可显著提高MMSE和ADL.评分,差异有统计学意义(P<0.05),mCBF有显著性差异(P<0.01)。结论:尼荧地平联合银杏叶片治疗VD安全有效,其作用机制可能与增加VD患者的脑血流量有关。

Efficacy of Nimodipine in Combination with Ginkgo Leaf Tablet in Patients with Vascular Dementia

Objective:To observe the efficacy of Nimodipine combined with and Ginkgo leaf tablet in vascular dementia(VD).Methods:Eighty-three VD patients were randomly divided to control group (n=41) and combination group(n=42).The two groups were given conventional treatment,and the combination group was treated with Nimodipine and Ginkgo leaf tablet.MMSE and ADL were used to estimate the therapeutic effect.Mean cerebral blood flow(mCBF) before and after the treatment was detected.Results:There were no significant differences in MMSE,ADL scores and mCBF in the control group.In the combination group,the MMSE and ADL scores,as well as mCBF,were significantly increased after the treatment(P <0.05,P <0.01 respectively).Conclusion:The combination therapy of Nimodipine and Ginkgo leaf tablet is effective for VD,probably by way of increasing the cerebral blood flow.