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| 妊娠期轻度甲状腺功能减退对子代远期智力的影响研究进展 | |
| 引用本文： | 高雪,龙燕,蔺莉.妊娠期轻度甲状腺功能减退对子代远期智力的影响研究进展[J].中国全科医学,2020,23(15):1838-1842. |
| 作者姓名： | 高雪 龙燕 蔺莉 |
| 作者单位： | 1.100050 北京市，首都医科大学附属北京友谊医院妇产科 2.102206 北京市，北京大学国际医院妇产科 *通信作者：龙燕，副教授，主任医师；E-mail：longyan_doc@126.com 蔺莉，教授，主任医师；E-mail：linli@pkuih.edu.cn |
| 基金项目： | 基金项目：首都医学科研发展基金资助项目（2016-1-1113） |
| 摘 要： | 妊娠期母体患有明显的甲状腺功能减退时会对子代的远期智力造成不良影响。本文主要对妊娠期母体轻度甲状腺功能减退对子代远期智力的影响进行综述，得出母体轻度甲状腺功能减退可能影响子代的智力发育，但是对于引起这种变化的具体机制以及如何消除这类危险因素，目前还没有确切的方案，仍需大量临床试验和基础实验提供治疗依据。 |
| 关 键 词： | 妊娠并发症 甲状腺功能减退症 妊娠期 低甲状腺素血症 子代智力 |
Recent Developments in Long-term Effects of Mild Hypothyroidism During Pregnancy on Offspring Intelligence |
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| GAO Xue,LONG Yan,LIN Li.Recent Developments in Long-term Effects of Mild Hypothyroidism During Pregnancy on Offspring Intelligence[J].Chinese General Practice,2020,23(15):1838-1842. | |
| Authors: | GAO Xue LONG Yan LIN Li |
| Affiliation: | 1.Department of Gynecology and Obstetrics，Beijing Friendship Hospital，Capital Medical University，Beijing 100050，China 2.Department of Gynecology and Obstetrics，Peking University International Hospital，Beijing 102206，China *Corresponding authors：LONG Yan，Associate professor，Chief physician；E-mail： longyan_doc@126.com LIN Li，Professor，Chief physician；E-mail：linli@pkuih.edu.cn |
| Abstract: | There are substantial available data showing impaired child intelligence resulting from overt maternal hypothyroidism during pregnancy.This review addresses the effect of mild maternal hypothyroidism on long-term development of intelligence of children.It is concluded that mild maternal hypothyroidism may affect children's mental development.However，the mechanisms that cause this change and how to eliminate these risk factors remain unclear and a large number of clinical and basic experiments are still required to provide evidence for treatment. |
| Keywords: | Pregnancy complications Hypothyroidism Duration of pregnancy Hypothyroxemia Offspring intelligence |
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