Phytochemistry and biological activities of Phlomis species |
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Authors: | Ilef Limem-Ben Amor Jihed Boubaker Mohamed Ben Sgaier Ines Skandrani Wissem Bhouri Aicha Neffati Soumaya Kilani Ines Bouhlel Kamel Ghedira Leila Chekir-Ghedira |
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Affiliation: | aLaboratory of Cellular and Molecular Biology, Faculty of Dental Medicine, Rue Avicenne, 5019 Monastir, Tunisia;bUnity of Pharmacognosy/Molecular Biology 99/UR/07-03, Faculty of Pharmacy, Rue Avicenne, 5000 Monastir, Tunisia |
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Abstract: | The genus Phlomis L. belongs to the Lamiaceae family and encompasses 100 species native to Turkey, North Africa, Europe and Asia. It is a popular herbal tea enjoyed for its taste and aroma. Phlomis species are used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation, and wounds. This review aims to summarize recent research on the phytochemistry and pharmacological properties of the genus Phlomis, with particular emphasis on its ethnobotanical uses. The essential oil of Phomis is composed of four chemotypes dominated by monoterpenes (α-pinene, limonene and linalool), sesquiterpenes (germacrene D and β-caryophyllene), aliphalic compounds (9,12,15-octadecatrienoic acid methyl ester), fatty acids (hexadecanoic acid) and other components (trans-phytol, 9,12,15-octadecatrien-1-ol). Flavonoids, iridoids and phenylethyl alcohol constitute the main compounds isolated from Phlomis extracts. The pharmacological activities of some Phlomis species have been investigated. They are described according to antidiabetic, antinociceptive, antiulcerogenic, protection of the vascular system, anti-inflammatory, antiallergic, anticancer, antimicrobial and antioxidant properties. |
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Keywords: | Phlomis Lamiaceae Secondary metabolites Ethnobotanical uses Pharmacological properties |
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