急性冠状动脉综合征患者血清基质金属蛋白酶-2与C-反应蛋白水平

目的:在血清学水平上探讨C反应蛋白(CRP)、基质金属蛋白酶2(MMP2)与冠状动脉粥样硬化斑块破裂的关系,评价CRP、MMP2水平作为粥样硬化斑块破裂的血清学指标的意义。方法:分别利用酶联免疫吸附法及散射比浊法对40例急性冠状动脉综合征(ACS)组、40例稳定型心绞痛(SAP)组、40例非冠心病者(正常对照组)外周血血清CRP、MMP2水平进行测定。结果:ACS组、SAP组血清CRP、MMP2水平明显高于正常对照组,差异具有统计学意义(P<0.01),ACS组血清CRP、MMP2水平明显高于SAP组,差异具有统计学意义(P<0.01);经相关性检验血清CRP和MMP2水平呈明显正相关(P<0.01)。结论:血清CRP、MMP2水平可反映斑块稳定性,可作为检测斑块破裂的血清学指标。

Approach of clinical significance of serum C-respective protein and matrix metalloproteinases-2 levels in acute coronary syndrome patients

Objective:To investigate the relationship between serum levels of C-respective protein (CRP)and matrix metalloproteinases-2(MMP-2) and coronary atherosclerotic plaque rupture and its significance as serum target of plaque rupture. Method:The levels of CRP and MMP-2 in peripleral serum of 40 acute coronary syndrome(ACS) patients, stable angina pectoris(SAP) patients and 40 without coronary heart disease patients as control were measured, respectively by enzyme-linked immunoassay(ELISA) and scatter rateturbidity.Result:The serum levels of CRP and MMP-2 in ACS group, SAP group were higher than that in without coronary heart disease group.The levels of CRP and MMP-2 in ACS group were higher than that in SAP group.There was a positive correlation between the levels of CRP and MMP-2. Conclusion:Elevation of serum level of CRP and MMP-2 are related with unstable plaque. It can be used as a serum target to judge plaque rupture.