| 从黄皮茎枝中分离到的一个新的咔唑生物碱 |
| |
| 引用本文： | 马洁,孙兴妍,臧应达,蒙建州,李创军,杨敬芝,张东明. 从黄皮茎枝中分离到的一个新的咔唑生物碱[J]. 药学学报, 2020, 0(1): 110-112 |
| |
| 作者姓名： | 马洁 孙兴妍 臧应达 蒙建州 李创军 杨敬芝 张东明 |
| |
| 作者单位： | 中国医学科学院、北京协和医学院药物研究所;中国医学科学院、北京协和医学院医药生物技术研究所 |
| |
| 基金项目： | 北京市自然科学基金青年项目(7194299);国家自然科学基金(NSFC 81730093);中国医学科学院医学与健康科技创新工程(CAMS-I2M-1-010,2016-I2M-2-003,2017-I2M-3-010) |
| |
| 摘 要： | 采用HPD100大孔树脂、PRP-512A大孔树脂、硅胶、ODS制备色谱柱等方法,从黄皮茎枝中分离得到1个新的咔唑生物碱化合物,通过UV、IR、HR-ESI-MS、1D/2DNMR、ECD等光谱分析方法对其进行结构鉴定,确定其结构,并命名为Claulamine F (1)。通过抗菌实验筛选,未发现其对金葡菌、绿脓杆菌、大肠杆菌具有显著活性。此外,通过MTT法,化合物1未显示其对5种肿瘤细胞株具有明显细胞毒活性。
|
| 关 键 词： | 黄皮 化学成分 咔唑生物碱 抗菌 细胞毒活性 |
A new carbazole alkaloid from the stems of Clausena lansium |
| |
| MA Jie,SUN Xing-yan,ZANG Ying-da,MENG Jian-zhou,LI Chuang-jun,YANG Jing-zhi,ZHANG Dong-ming. A new carbazole alkaloid from the stems of Clausena lansium[J]. Acta pharmaceutica Sinica, 2020, 0(1): 110-112 |
| |
| Authors: | MA Jie SUN Xing-yan ZANG Ying-da MENG Jian-zhou LI Chuang-jun YANG Jing-zhi ZHANG Dong-ming |
| |
| Affiliation: | (.State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China) |
| |
| Abstract: | A new carbazole alkaloid was isolated from the aqueous extract of the stems of Clausena lansium(Lour.) Skeels by various chromatographic methods, including HPD-100, PRP-512 A, silica gel, and reverse phase C18. Its structure was determined by spectroscopic and chemical methods, including UV, IR, HR-ESI-MS, 1 D/2 DNMR and ECD. Compound 1, named as Claulamine F, showed no antimicrobial activity on Staphylococcus aureus, Escherichia coli or Pseudomonas aeruginosa. In addition, compound 1 exhibited no cytotoxicity on five kinds of cancer cells through MTT methods. |
| |
| Keywords: | Clausena lansium(Lour.) Skeels chemical constituent carbazole alkaloid antimicrobial cytotoxicity |
| 本文献已被 维普 等数据库收录！ |
|
