| Stathmin及Cathepsin B在结直肠癌中的表达 |
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| 引用本文： | 杨正多,张丹,吕宏程,张丽,刘光,马卉,王刚,张诗武. Stathmin及Cathepsin B在结直肠癌中的表达[J]. 中华结直肠疾病电子杂志, 2015, 4(1): 45-49. DOI: 10.3877/cma.j.issn.2095-3224.2015.01.10 |
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| 作者姓名： | 杨正多 张丹 吕宏程 张丽 刘光 马卉 王刚 张诗武 |
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| 作者单位： | 1. 300121 天津，南开大学人民医院病理科 |
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| 摘 要： | 目的研究Stathmin和Cathepsin B在人结直肠癌组织及其转移灶中的表达差异，探讨Stathmin和Cathepsin B在结直肠癌发生发展过程中的作用及其临床病理意义。 方法用免疫组织化学染色技术检测158例高分化，中分化及低分化结直肠癌患者手术切除标本及64例相应转移灶组织中Stathmin蛋白和Cathepsin B蛋白的表达情况。 结果Stathmin蛋白及Cathepsin B蛋白在结直肠癌组织及其转移灶中均高表达(分别为P<0.05及P<0.01)；高分化结直肠癌样本中Stathmin蛋白及Cathepsin B蛋白在细胞膜或细胞浆阳性表达，而在低分化结直肠癌细胞核，细胞膜及细胞浆中可见二者的阳性表达。 结论Stathmin及Cathepsin B可能是判断结直肠癌患者临床病理分级的有用指标。
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| 关 键 词： | 结直肠肿瘤 Stathmin Cathepsin B |
| 收稿时间： | 2014-11-07 |
Expression of stathmin and cathepsin B in colorectal cancer |
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| Zheng-duo YANG,Dan ZHANG,Hong-cheng LV,Li ZHANG,Guang LIU,Hui MA,Gang WANG,Shi-wu ZHANG. Expression of stathmin and cathepsin B in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 4(1): 45-49. DOI: 10.3877/cma.j.issn.2095-3224.2015.01.10 |
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| Authors: | Zheng-duo YANG Dan ZHANG Hong-cheng LV Li ZHANG Guang LIU Hui MA Gang WANG Shi-wu ZHANG |
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| Affiliation: | 1. Department of Pathology, Nankai University Affiliated Hospital, Tianjin 300121, China |
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| Abstract: | ObjectiveTo investigate the differential expression of Stathmin and Cathepsin B in human colorectal cancer tissues and related metastatic foci and its clinicopathological significance. MethodsImmunohistochemical staining for Stathmin and Cathepsin B was performed in 158 cases of colorectal cancer tissues and related 64 cases of metastatic foci within the tissue microarray. ResultsBoth Stathmin and Cathepsin B are upregulated in colorectal cancer and related metastatic samples(P<0.05 and P<0.01 respectively). The location of Stathmin and Cathepsin B transferred from cytoplasm to nuclear in low differentiation colorectal cancer samples compared with high to mediate differentiation samples. ConclusionStathmin and Cathepsin B may be valuable biomarkers for clinical differentiation of colorectal cancer. |
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| Keywords: | Colorectal neoplasms Stathmin Cathepsin B |
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