Rituximab in rheumatoid arthritis-associated peripheral ulcerative keratitis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Rituximab in rheumatoid arthritis-associated peripheral ulcerative keratitis

Authors:	Albert M Beltrán E Martínez-Costa L

Affiliation:	1. Servicio de Oftalmología, Hospital Dr. Peset, Valencia, España;2. Servicio de Reumatología, Hospital Dr. Peset, Valencia, España;1. Departamento de Oftalmología, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain;2. Instituto de Investigación Ramón Castroviejo, Madrid, Spain;1. Department of Health Science, School of Medicine, “Maggiore della Carità” Hospital, University of Eastern Piedmont “Amedeo Avogadro”, via Solaroli 17, 28100, Novara, Italy;2. Neurosurgery Unit, “Maggiore della Carità” Hospital, Corso Mazzini 18, 28100, Novara, Italy;3. Department of Pathology, “Maggiore della Carità” Hospital, University of Eastern Piedmont “Amedeo Avogadro”, Corso Mazzini 18, 28100, Novara, Italy;4. Diagnostic Radiology Unit, “SS Trinità” Hospital, Viale Zoppis 10, 28021, Borgomanero, Italy;5. Laboratory of Oncologic and Transplantation Molecular Pathology, Department of Pathology, S.Orsola-Malpighi Hospital, University of Bologna, Via Pietro Albertoni, 15,40138, Bologna, Italy;1. Servicio Clínico de Enfermedades Intersticiales del Pulmón Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Mexico;2. Servicio Clínico de Enfermedades Intersticiales del Pulmón, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico;1. Service de dermatologie, CHU de Martinique, CS 90632, 97261 Fort-de-France cedex, France;2. Service de chirurgie thoracique, CHU de Martinique, CS 90632, 97261 Fort-de-France cedex, France;3. Service d’anatomopathologie, CHU de Martinique, CS 90632, 97261 Fort-de-France cedex, France;4. Service de médecine interne, CHU de Martinique, CS 90632, 97261 Fort-de-France cedex, France;5. DRCI, CHU de Martinique, CS 90632, 97261 Fort-de-France cedex, France;1. Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain;2. Servicio de Oftalmología, Hospital Clínico San Carlos, Departamento de Inmunología, Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain

Abstract:	CLINICAL CASE: We report two cases of patients affected by longstanding rheumatoid arthritis who developed a severe form of peripheral ulcerative keratitis (PUK). Neither of them had an optimal biological and clinical control of their systemic illness despite being treated with several disease-modifying antirheumatic drugs (DMARDs) and biologic therapy. High-dose systemic corticosteroids were given to treat the PUK without any success. Rituximab resulted in a favourable response with resolution of the corneal lesions and optimal control of their systemic illness. DISCUSSION: Rituximab may be an additional tool to arrest progressive rheumatoid arthritis-associated PUK that is refractory to other drugs.

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