| 肝细胞刺激物质对大鼠实验性肝纤维化的治疗研究 |
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| 引用本文： | 李楠,李安信.肝细胞刺激物质对大鼠实验性肝纤维化的治疗研究[J].解放军医学杂志,1991,16(6):438-441. |
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| 作者姓名： | 李楠 李安信 |
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| 作者单位： | 海军总医院消化内科，302医院生物工程研究室，302医院生物工程研究室 |
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| 摘 要： |
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| 关 键 词： | 肝脏纤维化 四氯化碳 HSS |
EXPERIMENTAL TREATMENT OF CCl_4 INDUCED HEPATIC FIBROSIS OF RATS WITH HEPATOCYTE STIMULATING SUBSTANCE |
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| Li Nan,Li Anxin,Jiangfan,Chen Jumei.EXPERIMENTAL TREATMENT OF CCl_4 INDUCED HEPATIC FIBROSIS OF RATS WITH HEPATOCYTE STIMULATING SUBSTANCE[J].Medical Journal of Chinese People's Liberation Army,1991,16(6):438-441. |
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| Authors: | Li Nan Li Anxin Jiangfan Chen Jumei |
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| Affiliation: | Li Nan,Li Anxin,Jiangfan,Chen Jumei. Department of Biotechnology Research,302 Hospital,PLA. Beijing |
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| Abstract: | In this paper, we report the experimental treatment of CCl4 induced hepatic fibrosis of rats with hepatocyte stimulating substance (HSS), as well as their hydroxyproline trend. The results revealed that the hepatic hydroxyproline contents of the HSS-treated and HSS-prevented animals were significantly less than those of the control group (P<0.01). The serum albumin levels of HSS prevented animals exceeded other groups (P<0.05). Hepatocyte degeneration and fibrous tissue hyperplasia in HSS-treated and HSS-prevented group were significantly less than control (P<0.05). Blood ALT levels showed no statistically valid diference among three groups. This suggested that HSS inhibited hepatic fibrosis and improved hepatic systhesis function. This effect might be due to the stimulating action of HSS particu-lary on damaged liver cells, promoting regeneration, and selectively increased the resolution of collagen. |
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| Keywords: | Hepatic fibrosis CCl4 Hydroxyproline Hepatocyte stimulating substance |
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