| 沙芬酰胺的合成 |
| |
| 引用本文： | 邢瑞娟,律涛,刘磊娜,朱梦楚,杜玉民.沙芬酰胺的合成[J].中国医药工业杂志,2012,43(3):161-163. |
| |
| 作者姓名： | 邢瑞娟 律涛 刘磊娜 朱梦楚 杜玉民 |
| |
| 作者单位： | 1. 河北医科大学药学院药物化学教研室,河北石家庄,050017
2. 江苏大学基础医学与医学技术学院,江苏镇江,212013 |
| |
| 摘 要： | 3-氟氯苄与对羟基苯甲醛反应制得4-(3-氟苄氧基)苯甲醛,而后与(劝-2-氨基丙酰胺缩合、Pd/C催化氢化还原,最后与甲磺酸成盐制得抗帕金森病药沙芬酰胺,总收率约76％.
|
| 关 键 词： | 沙芬酰胺 抗帕金森病药 合成 |
Synthesis of Safinamide |
| |
| Authors: | XING Ruijuan L Tao LIU Leina ZHU Mengchu DU Yumin |
| |
| Affiliation: | 1(1.Dept.of Medicinal Chemistry,Hebei Medical University,Shijiazhuang 050017; 2.School of Medical Science and Lab.Medicine,Jiangsu University,Zhenjiang 212013) |
| |
| Abstract: | Safinamide,an antiparkinson drug,was synthesized from 3-fluorobenzyl chloride by substitution with 4-hydroxybenzaldehyde to give 4-(3-fluorobenzyloxy)benzaldehyde,which was subjected to condensation and reduction to give(S)-2-4-(3-fluorobenzyloxy)benzylamino]propionamide,followed by salification with methanesulfonic acid.The overall yield was about 76%. |
| |
| Keywords: | safinamide antiparkinsonism drug synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
