| 一种对阿尔茨海默病模型小鼠认知和记忆功能具有明显改善作用的中药方剂 |
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| 引用本文： | 孙华,胡愉,张建民,栗世铀,何维.一种对阿尔茨海默病模型小鼠认知和记忆功能具有明显改善作用的中药方剂[J].中国中药杂志,2003,28(8):751-754. |
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| 作者姓名： | 孙华 胡愉 张建民 栗世铀 何维 |
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| 作者单位： | 1. 中国医学科学院,协和医科大学,协和医院,中医科,北京100730
2. 中国医学科学院,基础医学研究所,中国协和医科大学,基础医学院,北京100005 |
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| 基金项目： | 美国中华医学基金会(CMB)资助(99-699) |
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| 摘 要： | 目的 :探索对阿尔茨海默病 (AD)病人认知和记忆能力具有明显改善作用的中药方剂。方法 :通过Balb/c小鼠侧脑室微量注射聚集态 β 淀粉样多肽 (β-AP25-35) ,建立模拟AD的小鼠动物模型 ,并通过行为学实验和脑组织组织化学检测 ,研究了中医经典药方柴胡加龙骨牡蛎汤、当归芍药散和作者自己研制的两种中药复方CHPI和CHPⅡ对该小鼠模型认知和记忆能力的疗效作用。同时 ,以西药脑复康做对照。结果 :CHPⅡ对AD模型小鼠的认知和记忆能力具有明显的改善。结论 :本研究提示从中药中寻找治疗AD的药物具有较好的前景。
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| 关 键 词： | β-淀粉样多肽 AD模型小鼠 认知 记忆 中药 |
| 文章编号： | 1001-5302(2003)08-0751-04 |
| 收稿时间： | 2002/10/21 0:00:00 |
| 修稿时间： | 2002年10月21 |
Effects of One Chinese Herbs on Improving Cognitive Function and Memory of Alzheimer's Disease Mouse Models |
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| SUN Hua ;HU Yu ;ZHANG Jian min ;LI Shi you ;HE Wei.Effects of One Chinese Herbs on Improving Cognitive Function and Memory of Alzheimer''s Disease Mouse Models[J].China Journal of Chinese Materia Medica,2003,28(8):751-754. |
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| Authors: | SUN Hua ;HU Yu ;ZHANG Jian min ;LI Shi you ;HE Wei |
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| Affiliation: | Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, China. |
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| Abstract: | OBJECTIVE: To investigate Chinese herbs with the effect on significantly improving the cognitive function and retention of patients with Alzheimer's disease. METHOD: AD mouse models were established by injecting poly-beta-AP25-35 into the cerebral ventricle of mice. The curative effects of traditional Chinese herbs Dangguishaoyaosan, Chaihujialonggumulitang and two herbs (CHP I and CHP II) developed by the authors on improving the memory and cognitive function of AD mouse models were studied by the detection of behavioral and histochemical tests, with piracetam serving as control. RESULT: CHP II has profound curative effects on improving the memory and cognitive function of AD-like animal model. CONCLUSION: The present study indicates that it has a satisfactory prospect to seek new drugs from Chinese herbs to treat AD. |
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| Keywords: | amyloid peptide AD mouse model cognation retention Chinese herbs Alzheimer's disease |
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