青年脑出血急性期血肿体积与血压变异性的关系研究

目的：探讨青年脑出血患者的血压变异性（BPV）与急性期血肿体积的关系。方法：以首发青年脑出血（≤45岁）急性患者为研究对象，记录其人口统计学特征、神经功能缺失评分（NIHSS评分）；进行颅脑CT扫描，计算最大血肿体积；监测24小时动态血压、计算24小时收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）及血压变异度（BPV）；出院后随访其康复情况（mRS评分）。结果：患者收缩压变异度（SBPV）、舒张压变异度（DBPV）与血肿体积有显著关系（P〈0.05）；血肿体积及NIHSS评分与患者早期预后显著相关（P〈0．05）。结论：青年脑出血患者SBPV及DBPV增加可能提示血肿体积大，而后者常提示预后不佳。

Relationship of acute hematoma volume and blood pressure variability after intracerebral hemorrhage in young adults

Objective To evaluate the relationship between blood pressure variability （BPV） and hematoma volume in young patients with cerebral hemorrhage. Methods We prospectively evaluated 83 young patients younger than or equal to 45 years old who suffered from intracerebral hemorrhage. Recorded demographic characteristics and NIH Stroke Scale scores were recorded at baseline. Each patient underwent brain CT scan to calculate the max-hematoma volume. The next day we checked hematological indicators including fasting blood glucose,coagulation,blood lipids. ABP monitoring was performed during 24 hours after admission. Then 24-hour systolic blood pressure（SBP）, diastolic blood pressure（DBP）, mean arterial pressure （MAP） and blood pressure variability （BPV） were calculated; Modified Rankin Scale（mRS）was used to assess clinical outcome after discharge. Results Univariate analysis indicated that systolic blood pressure variability（SBPV）, diastolic blood pressure variability（DBPV）and hematoma volume were significantly related （P 〈0.05）. Hematoma volume and NIHSS score in patients were associated with unfavorable outcome assessed on mRS during the follow-up（P〈0.05）. ConclusionsThe increase of SBPV and DBPV in young adults with cerebral hemorrhage may suggest prompt hematoma volume increase, which often indicates a poor prognosis.