血浆NT-proBNP水平与同型半胱氨酸对糖尿病合并心房颤动的相关性研究

目的 探讨2型糖尿病合并心房颤动患者血N末端B型利钠肽原水平与同型半胱氨酸相关性。方法 选取2016年1月~2017年1月在我院接受治疗的T2DM患者120例，根据其有无心房颤动将患者分为房颤组(48例)和无房颤组（72例），所有患者均采用全自动生化分析仪检测血浆NT-proBNP及Hcy的水检测，观察两组血浆NT-proBNP水平与同型半胱氨酸的相关性。结果 观察组血浆NT-proBNP、Hcy均高于对照组，差异有统计学意义（P＜0.05）；观察组血浆NT-proBNP水平与Hcy呈正相关(r=0.328，P＜0.05)；两组间LAD、LVDD、LVEF、糖尿病病程相比较，差异无统计学意义(P＞0.05)。房颤组血浆NT-proBNP水平、Hcy高于无房颤组，差异有统计学意义（P＜0.05），血浆NT-proBNP水平与Hcy呈正相关(r=0.328，P＜0.05)。结论血浆NT-proBNP、Hcy为糖尿病并发房颤的危险因素。可通过联合检测血浆NT-proBNP及Hcy的水平预知糖尿病发生房颤的可能。

Correlation between Plasma NT-proBNP level and Homocysteine in Patients with Diabetes Mellitus Complicated with Atrial Fibrillation

Abstract:Objective To investigate the relationship between plasma N-terminal type B natriuretic peptide and homocysteine in patients with type 2 diabetes mellitus complicated with atrial fibrillation.Methods 120 patients with T2DM who were treated in our hospital from January 2016 to January 2017 were selected.Patients were divided into atrial fibrillation group(n=48)and non-atrial fibrillation group(n=72)according to their presence or absence of atrial fibrillation.The plasma NT-proBNP and Hcy were detected by automatic biochemical analyzer,and the correlation between plasma NT-proBNP and homocysteine was observed.Results The plasma NT-proBNP and Hcy levels in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05),the plasma NT-proBNP level in the observation group was positively correlated with Hcy(r=0.328,P< 0.05),there was no significant difference in the duration of LAD,LVDD,LVEF and diabetes between the two groups(P>0.05).The plasma NT-proBNP level and Hcy in the atrial fibrillation group were higher than those in the non atrial fibrillation group,the difference was statistically significant(P<0.05),and the plasma NT-proBNP level was positively correlated with Hcy(r=0.328,P<0.05). Conclusion Plasma NT-proBNP and Hcy are risk factors for diabetes mellitus complicated with atrial fibrillation.The possibility of atrial fibrillation in diabetes can be predicted by combined detection of plasma NT-proBNP and Hcy levels.