| 正交试验法优化透肤洗剂的提取工艺 |
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| 引用本文： | 彭勇,陈汝静,刘朵,柴维汉,朱全刚. 正交试验法优化透肤洗剂的提取工艺[J]. 药学实践杂志, 2018, 36(2): 173-175 |
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| 作者姓名： | 彭勇 陈汝静 刘朵 柴维汉 朱全刚 |
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| 作者单位： | 上海市嘉定区中医医院, 上海 201899,上海市皮肤病医院, 上海 200443,上海市嘉定区中医医院, 上海 201899,上海市嘉定区中医医院, 上海 201899,上海市皮肤病医院, 上海 200443 |
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| 基金项目： | 上海市进一步加快中医药事业发展三年行动计划项目（ZY3-JSFC-2-2001）；上海市科委创新行动计划生物医药项目（17401901800） |
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| 摘 要： | 目的 优化透肤洗剂的提取工艺，提高透肤洗剂的质量。方法 采用正交试验法，以加水量、提取时间、提取次数为考察因素，以苦参碱的含量为考察指标，优化提取工艺。结果 最佳提取工艺的加水量是饮片量的8倍，提取2次，每次90 min。结论 该工艺合理可行、稳定性好，可保证制剂质量。
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| 关 键 词： | 透肤洗剂 苦参碱 正交试验 |
| 收稿时间： | 2017-11-27 |
| 修稿时间： | 2017-12-04 |
Optimization of extraction technology for Toufu irrigation by orthogonal test |
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| PENG Yong,CHEN Rujing,LIU Duo,CHAI Weihan and ZHU Quangang. Optimization of extraction technology for Toufu irrigation by orthogonal test[J]. The Journal of Pharmaceutical Practice, 2018, 36(2): 173-175 |
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| Authors: | PENG Yong CHEN Rujing LIU Duo CHAI Weihan ZHU Quangang |
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| Affiliation: | Shanghai Jiading Hospital of TCM, Shanghai 201899, China,Shanghai Dermatology Hospital, Shanghai 200443, China,Shanghai Jiading Hospital of TCM, Shanghai 201899, China,Shanghai Jiading Hospital of TCM, Shanghai 201899, China and Shanghai Dermatology Hospital, Shanghai 200443, China |
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| Abstract: | Objective To optimize the extraction process and improve the quality of Toufu irrigation. Methods Matrine assay was selected to be the indicator for the extraction efficacy. Orthogonal test was used to determine the optimal water amount, extraction time and extraction frequency. Results The best extraction process was to extract 90 minutes twice with the water amount 8 times of the dry herbal material by weight. Conclusion This process is feasible and repeatable. It can be used for the quality control of the preparation. |
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| Keywords: | Toufu irrigation matrine orthogonal test |
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