黄花败酱草和白花败酱草的化学成分与药理作用研究进展

败酱草为我国传统中药,始载于《神农本草经》,具有清热解毒、利湿排脓、活血化瘀的功效。临床上常用于治疗肠痈、肺痈、痈肿疮毒和产后瘀阻腹痛等症。近年来化学成分研究显示败酱草中含有三萜类、黄酮类、环烯醚萜类、甾醇、香豆素及有机酸类,药理研究发现败酱草具有抑菌、镇静、胃肠、抗肿瘤、抗氧化及抗前列腺增生的作用。其来源植物黄花败酱草和白花败酱草的化学成分和药理作用存在一定差异,因此对两种来源败酱草的化学成分及药理作用的研究情况进行综述,为深度研究与开发提供参考。

Research progress on chemical constituents and pharmacological effects of Patrinia scabiosaefolia and Patrinia villosa

Patriniae Herba is a traditional Chinese medicine, originally recorded in "Shengnong''s Herbal Classic" with clearing heat and detoxicating, removing dampness and apocenosis, and promoting blood circulation to remove blood stasis. Commonly it was used in clinical treatment of lung abscess, appendicitis, carbuncle sore, and postpartum blood stasis symptoms such as abdominal pain. In recent years, large quantities of triterpenes had been isolated from the plant, together with other types of active principles, such as flavonoids, iridoids, sterols, coumarins, and organic acids. Patriniae Herba had the antibacterial, sedation, gastrointestinal, antitumor, anti-oxidant, and antihyperplasia effects. There are some differences in the chemical constituents and pharmacological effects between Patrinia scabiosaefolia and P. villosa, so this paper reviewed the chemical composition and pharmacological action of two sources of Patriniae Herba, in order to provide reference for the research and development of Patriniae Herba.