TiO2/PVDF共混微滤膜的制备及其吸附胆红素的研究

胆红素是一种内源性毒素，当人体肝脏系统受损或代谢受阻时，则在体内累积，引起高胆红素血症，其具有神经毒性，严重时甚至会危及生命。无机纳米材料作为胆红素吸附剂越来越受到关注，但也存在因团聚而吸附效率降低、因颗粒过小而容易泄漏的问题。以聚偏氟乙烯(PVDF)为基膜原料，掺杂纳米TiO₂颗粒，DMAc为溶剂、PVP为致孔剂，通过干湿相转化法，制得TiO₂/PVDF共混微滤膜。当铸膜液中PVDF浓度为10%(质量)、TiO₂含量为1%(质量)、PVP含量为6%(质量)时，制备的TiO₂/PVDF共混微滤膜的胆红素特异性吸附显著。电镜照片及EDX能谱发现，该膜内部及孔隙中均匀分布TiO₂颗粒，颗粒无团聚现象。实验还考察了胆红素初始浓度、吸附时间、吸附温度、pH等吸附条件的影响。

Preparation of TiO2/PVDF blend microfiltration membrane and its adsorption of bilirubin

Bilirubin is an endogenous toxin, and accumulated in the body when hepatic injure is happened and excretion is hindered. The high level of bilirubin in the body, i.e., hyperbilirubinemia, manifests neurotoxicity, and threatens life even in serious case. Inorganic nanomaterials have attracted more and more attention as bilirubin adsorbents. However, some problems in bilirubin adsorption with using nanomaterials exist such as a decreasing adsorption efficiency due to agglomeration, and easy leakage because of small particle size. In this paper, TiO₂/PVDF blend microfiltration membrane was prepared by dry-wet phase inversion, which the polyvinylidene fluoride (PVDF) as a matrix material, blended with nano-TiO₂ particles, DMAc as solvent and PVP as porogen. When PVDF concentration was 10%(mass), TiO₂ content was 1%(mass) and PVP content was 6%(mass), the prepared TiO₂/PVDF blend microfiltration membrane showed significantly specific adsorption for bilirubin. SEM and EDX showed that TiO₂ particles were evenly distributed in the membrane and in the pores without agglomeration. The effects of initial bilirubin concentration, adsorption time, adsorption temperature, pH and other adsorption conditions were also investigated.