反复呼吸道感染患儿口含干扰素片后T细胞亚群与sIL-2R的变化

目的：了解口含干扰素片治疗儿童反复呼吸道感染（ＲＲＩ）的效果。方法：检测了口含干扰素和常规治疗组ＲＲＩ患儿在治疗前后Ｔ淋巴细胞亚群和血清ｓＩＬ２Ｒ水平，并与正常健康儿童对照。结果：口含干扰素片治疗后患儿ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８均显著升高，ＣＤ８水平和血清ｓＩＬ２Ｒ水平显著降低，ＣＤ４、ＣＤ８、ｓＩＬ２Ｒ水平与正常对照组相比均无明显差异，经常规治疗的患儿仅ＣＤ４、ＣＤ４／ＣＤ８显著升高，ＣＤ３、ＣＤ８水平和血清ｓＩＬ２Ｒ水平在治疗前后均无显著差异，与正常对照组相比，除ＣＤ４外其余各项指标均差异显著，且口含干扰素片治疗后患儿ＣＤ３、ＣＤ４／ＣＤ８显著高于常规治疗的患儿（Ｐ＜０．００１），而ＣＤ８、ｓＩＬ２Ｒ水平则显著低于常规治疗组（Ｐ＜０．００１）。结论：口含干扰素片治疗后患儿的细胞免疫状态优于常规治疗的患儿。

Changes of T lymphocyte subtypes and sIL 2R of children with RRI treated with interferon buccal tablets

Aim: To investigate the effects of interferon buccal tablets on children with recurrent respiratory infections(RRI). Methods: In two groups of children with RRI treated with interferon buccal tablets or routine therapy,T lymphocyte subtypes and serum sIL 2R were compared after two different treatments. Results: In RRI children treated with interferon buccal tablets, the CD3 + cells, CD4 + cells ,the ratio of CD4 +/CD8 + increased and the CD8 + cells and serum sIL 2R decrease significantly.The children treated with routine therapy had only increase of CD4 + cells and the ratio of CD4 +/CD8 +. The RRI children treated with interferon buccal tablets had no difference from the normal control in CD4 + cells, CD8 + cells and serum sIL 2R, indicating that immunity of the children has been improved;while the RRI children treated by routine therapy had significant difference from the normal control in CD3 + cells, CD8 + cells, the ratio of CD4 +/CD8 + and serum sIL 2R,indicating that immunity of the children has not been improved obviously.CD3 + cells and ratio of CD4 +/CD8 + of the RRI children treated with interferon buccal tablets were significantly higher and the CD8 + cells,sIL 2R were significantly lower than those of RRI children treated with routine therapy ( P <0.001). Conclusion: Ifmmunity of RRI children treated with interferon buccal tablets were significantly better than that of RRI children treated with routine therapy.