肿瘤核素靶向治疗新进展

利用靶向分子将放射性核素定向导入肿瘤组织实现核素靶向治疗是肿瘤治疗的重要方法。利用单克隆抗体或小分子肽携带治疗性放射性核素，分别与肿瘤细胞表面表达丰富的抗原或受体特异性结合而开展放射免疫治疗或受体介导的核素治疗是靶向治疗的主要策略。近年来，这两种靶向治疗取得较大进展，部分已进入临床应用。随着靶向分子的不断出现、分子靶向技术的不断完善，肿瘤核素靶向治疗终将成为肿瘤治疗的重要方法。

Advance progress of radionuclide target tumor therapy

Radionuclide internal therapy is an important method for tumor treatment. Radioimmunotherapy(RIT)and peptide receptor radionuclide therapy(PPRT)are two major strategies for tumor therapy by targeting antigen or receptor over-expressed in tumor cells with radionuclide labeled monoclonal antibody or peptide separately. RIT and PPRT have been dramatically developed with several agents have been used in clinic and more are underwent clinic or pre-clinic trial. The radionuclide therapy will play more important role in tumor therapy with the more specific target been selected and improvement of the methods.