Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation |
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Authors: | Louie Elizabeth Nik Sara Chen Juei-Suei Schmidt Marlies Song Bo Pacson Christine Chen Xiu Fang Park Seonhye Ju Jingfang Chen Emily I |
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Affiliation: | (1) Department of Pharmacological Sciences, Stony Brook University, BST-125, Stony Brook, NY 11794, USA;(2) Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA |
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Abstract: | Introduction The irregular vasculature of solid tumors creates hypoxic regions, which are characterized by cyclic periods of hypoxia and
reoxygenation. Accumulated evidence suggests that chronic and repetitive exposure to hypoxia and reoxygenation seem to provide
an advantage to tumor growth. Although the development of hypoxia tolerance in tumors predicts poor prognosis, mechanisms
contributing to hypoxia tolerance remain to be elucidated. Recent studies have described a subpopulation of cancer stem cells
(CSC) within tumors, which have stem-like properties such as self-renewal and the ability to differentiate into multiple cell
types. The cancer stem cell theory suggests CSCs persist in tumors as a distinct population and cause relapse and metastasis
by giving rise to new tumors. Since hypoxia is considered to be one of the critical niche factors to promote invasive growth
of tumors, we hypothesize that repetitive cycles of hypoxia/reoxygenation also play a role in the enrichment of breast CSCs. |
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