谷氨酰胺颗粒对化疗所致口腔黏膜炎的疗效分析

目的 探讨谷氨酰胺颗粒对肿瘤化疗所致口腔黏膜炎的疗效。方法 将91例化疗所致的口腔黏膜炎患者随机分为谷氨酰胺组(5g/10mL，漱口3次/d)46例，安慰剂组(生理盐水10mL，漱口3次/d)45例。两组均在化疗开始后每天使用谷氨酰胺（或安慰剂）治疗21天，按照WHO分级标准评价口腔黏膜炎的恢复状况并进行生活质量评分。结果 与安慰剂组相比，谷氨酰胺组明显降低了患者化疗后III、IV级口腔黏膜炎的比率（P<0.05）；明显提高了患者化疗后7、14、21d的生活质量评分（P<0.05)。同时，谷氨酰胺组比安慰剂组止痛药物应用、并发出血和使用全肠外营养的比例明显减少（P<0.05)。结论 谷氨酰胺颗粒剂含漱对肿瘤化疗导致的口腔黏膜炎有明确的疗效。

Glutamine granules for Oral Mucositis after Chemotherapy

Objective     To explore the efficacy of glutamine granules in the treatment of oral mucositis (OM) caused by chemotherapy. Methods   Ninety-one patients were divided into two groups randomly, in which 46 patients received glutamine granues (a gargle of 5g/10mL, 3 times/day) while the orther 45 received placebo (a gargle of 10mL, 3 times/day). All the cases must start with glutamine granules or placebo on the same day when chemotherapy began.  OM grade was evaluated  according to the gradings issued by WHO. Meanwhile, the score of quality of life was also recorded. Results    Compared with placebo, glutamine group significantly reduced the incidences of grade 3 and 4 OM （P<0.05 ). Glutamine also significantly enhanced the score of quality of life on the 7th, 14th and 21st day (P<0.05). Meanwhile, patients received glutamine used less pain killer (P<0.05) and showed low incidence of  bleeding (P<0.05). The necessity of total parenteral nutrition due to OM was also reduced considerably than that of placebo group(P<0.05). Conclusion     Glutamine granules is effective to treat OM in the patients receiving cytotoxic  chemotherapy.