SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses |
| |
Authors: | Seki Yoh-ichi Inoue Hiromasa Nagata Naoko Hayashi Katsuhiko Fukuyama Satoru Matsumoto Koichiro Komine Okiru Hamano Shinjiro Himeno Kunisuke Inagaki-Ohara Kyoko Cacalano Nicholas O'Garra Anne Oshida Tadahilo Saito Hirohisa Johnston James A Yoshimura Akihiko Kubo Masato |
| |
Affiliation: | Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278-0022, Japan. |
| |
Abstract: | Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation between SOCS-3 expression and the pathology of asthma and atopic dermatitis, as well as serum IgE levels in allergic human patients. SOCS-3 transgenic mice showed increased T(H)2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system. In contrast, dominant-negative mutant SOCS-3 transgenic mice, as well as mice with a heterozygous deletion of Socs3, had decreased T(H)2 development. These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of T(H)2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|