联合检测血清CYFRA21-1和SCC-Ag水平在诊断食管癌中的应用价值

目的 分析联合检测血清CYFRA21-1、SCC-Ag水平在诊断食管癌中的应用价值.方法 随机选取2014年7月至2016年7月肿瘤内科和消化内科就诊的食管癌患者874例为研究对象(试验组),同时期健康体检者874例为对照组,分别采集试验患者空腹5.0 ml静脉血,检测血清中细胞角蛋白19片段抗原(CYRRA21-1)和鱗状细胞癌相关抗原(SCC-Ag)的含量水平,应用SPSS 20.0统计软件进行分析.结果 (1)试验组CYRRA21-1高于对照组(38.19±49.75,4.86±2.79),试验组SCC-Ag高于对照组(28.77±52.26,2.05±1.83),2组比较差异有统计学意义(P<0.01).(2)CYRRA21-1和SCC-Ag在不同分化程度之间比较差异无统计学意义(P>0.05).(3)CYRRA21-1在试验组中的阳性率为79.75％,SCC-Ag在试验组中的阳性率为74.83％.(4)ROC曲线分析显示,CYRRA21-1和SCC-Ag的联合检测对诊断食管癌具有一定的指导意义,可以提高诊断的阳性率,特异性为100％.结论 细胞分化程度与血清CYRRA21-1和SCC-Ag含量水平无必然联系,联合诊断血清CYRRA21-1和SCC-Ag含量水平,有助于提高食管癌的诊断率,具有一定的应用价值.

Application value of combined detection of serum levels of CYFRA21-1 with SCC-Ag in diagnosis of esophageal cancer

Objective To analyze the application value of combined detection of serum levels of cell keratin 19 fragment antigen (CYRRA21-1) with squamous cell carcinoma associated antigen (SCC-Ag) in diagnosis of esophageal cancer.Methods A total of 874 patients with esophageal cancer who were treated in our hospital from July 2014 to July 2016 were enrolled as trial group,at the same time, 874 healthy subjects were enrolled as control group.The serum levels of cytokeratin 19 fragment antigen (CYRRA21-1) and squamous cell carcinoma antigen (SCC-Ag) were detected and compared between two groups.Results The levels of CYRRA21-1 in trial group were higher than those in control group (38.19± 49.75 vs 4.86±2.79),and the levels of SCC-Ag in trial group were higher than those in control group (28.77±52.26 vs 2.05±1.83),there were significant differences between two groups (P<0.01).However there were no significant differences in CYRRA21-1和SCC-Ag among different differentiation degrees of tumor (P>0.05).The positive rate of CYRRA21-1 in trial group was 79.75％,and the positive rate of SCC-Ag in trial group was 74.83％.ROC curve analysis showed that the combined detection of CYRRA21-1 with SCC-Ag had a certain guidance significance in diagnosis of esophageal cancer,which could increase positive rate of diagnosis,with specificity being 100％.Conclusion The cell differentiation degree is not necessarily correlated to serum levels of CYRRA21-1 and SCC-Ag,but combined detection of serum levels of CYRRA21-1 with SCC-Ag is helpful to improve diagnosis rate of esophageal cancer and has certain application value.