| 双波长紫外分光光度法测定肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯的含量 |
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| 引用本文： | 崔亚玲,马宏达,胡北,吴琼,侯明晓. 双波长紫外分光光度法测定肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯的含量[J]. 中国药师, 2015, 0(9): 1596-1598 |
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| 作者姓名： | 崔亚玲 马宏达 胡北 吴琼 侯明晓 |
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| 作者单位： | 沈阳军区总医院药剂科 沈阳 110016;沈阳军区总医院药剂科;沈阳军区总医院药剂科;沈阳军区总医院药剂科;沈阳军区总医院药剂科 |
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| 基金项目： | “十二五”国家科技重大新药创制专项军特需药物课题(编号：2013ZX09J13109-03B) |
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| 摘 要： | 摘 要 目的： 建立肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯的含量测定方法。方法: 采用双波长紫外分光光度法测定肌醇烟酸酯的含量。以262 nm为测定波长，246 nm为参比波长，ΔA ＝A262－A246为定量信息测定肌醇烟酸酯的含量。结果: 建立的肌醇烟酸酯含量测定方法可有效地消除基质对主药含量测定的干扰。肌醇烟酸酯在4~24 μg·ml-1浓度范围内与吸光度差值ΔA线性关系良好，r=0.999 9；低、中、高浓度的平均回收率为99.11%，RSD为1.70%(n=9)。结论: 该方法操作简便快捷，稳定性好，结果准确，可用于肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯的含量测定，有效控制该制剂的质量。
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| 关 键 词： | 双波长紫外分光光度法；肝素钠肌醇烟酸酯乳膏；肌醇烟酸酯；含量测定 |
| 收稿时间： | 2015-03-31 |
| 修稿时间： | 2015-05-19 |
Determination of Heparin and Inositol Nicotinate Cream by Dual wavelength Spectrophotometry |
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| Cui Yaling,Ma Hongd,Hu Bei,Wu Qiong and Hou Mingxiao. Determination of Heparin and Inositol Nicotinate Cream by Dual wavelength Spectrophotometry[J]. China Pharmacist, 2015, 0(9): 1596-1598 |
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| Authors: | Cui Yaling Ma Hongd Hu Bei Wu Qiong Hou Mingxiao |
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| Affiliation: | Department of Pharmacy, General Hospital of Shenyang Military Command Area, Shenyang 110016, China;Department of Pharmacy, General Hospital of Shenyang Military Command Area;Department of Pharmacy, General Hospital of Shenyang Military Command Area;Department of Pharmacy, General Hospital of Shenyang Military Command Area;Department of Pharmacy, General Hospital of Shenyang Military Command Area |
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| Abstract: | |
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| Keywords: | Dual wavelength spectrophotometry Heparin and inositol nicotinate cream Inositol nicotinate Determination |
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