Maternal Flaxseed Oil During Lactation Enhances Bone Development in Male Rat Pups |
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Authors: | Aline D’Avila Pereira Danielle Cavalcante Ribeiro Fernanda Carvalho de Santana Aline de Sousa dos Santos Jorge Mancini-Filho Celly Cristina Alves do Nascimento-Saba Luis Guillermo Coca Velarde Carlos Alberto Soares da Costa Gilson Teles Boaventura |
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Affiliation: | 1. , Laboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Fluminense Federal University, Niterói, RJ, Brazil;2. , Laboratory of Lipids, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of S?o Paulo, S?o Paulo, Brazil;3. , Physiological Sciences, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil;4. , Department of Statistics, Fluminense Federal University, Niterói, RJ, Brazil |
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Abstract: | Flaxseed oil is an alpha linolenic acid source important in the growth and body development stage; furthermore, this acid acts on adipose tissue and bone health. The aim of this study was to evaluate body composition, fatty acid composition, hormone profile, retroperitoneal adipocyte area and femur structure of pups at weaning, whose mothers were fed a diet containing flaxseed oil during lactation. After birth, pups were randomly assigned: control (C, n = 12) and flaxseed oil (FO, n = 12), rats whose mothers were treated with diet containing soybean or flaxseed oil. At 21 days, the pups were weaned and body mass, length, body composition, biochemical parameter, leptin, osteoprotegerin, osteocalcin, fatty acids composition, intra‐abdominal fat mass and femur structure were analyzed. FO showed (p < 0.05): higher body mass (+12 %) and length (+9 %); body fat mass (g, +45 %); bone mineral density (+8 %), bone mineral content (+55 %) and bone area (+35 %), osteocalcin (+173 %) and osteoprotegerin (+183 %). Arachidonic acid was lower (p < 0.0001), alpha‐linolenic and eicosapentaenoic were higher (p < 0.0001). Intra‐abdominal fat mass was higher (+25 %), however, the retroperitoneal adipocytes area was lower (?44 %). Femur mass (+10 %), distance between epiphyses (+4 %) and bone mineral density (+13 %) were higher. The study demonstrates that adequate flaxseed oil content during a lactation diet plays an important role in the development of pups. |
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Keywords: | Flaxseed oil Rats Lactation Adiposity Bone |
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