西拉普利联合拉西地平对高血压患者血管活性物质和颈动脉粥样硬化的影响

目的探讨西拉普利联合拉西地平对高血压患者血管活性物质和颈动脉粥样硬化的影响。方法选取2018年1月至2018年12月于青岛市市立医院就诊的110例高血压患者随机分为对照组(53例)和观察组(57例),对照组采用西拉普利治疗,观察组在对照组基础上联合拉西地平治疗,比较两组患者的临床疗效,并对比两组患者治疗前后血压、血管活性物质、颈动脉内膜中层厚度(IMT)、斑块厚度、斑块长度变化情况,记录药物不良反应。结果两组患者的总有效率比较,差异无统计学意义(P>0.05)。治疗前两组收缩压(SBP)、舒张压(DBP)、内皮素(ET)、血管紧张素Ⅱ(AngⅡ)、一氧化氮(NO)、IMT、斑块厚度、斑块长度比较均无统计学意义(P>0.05);治疗后两组SBP、DBP、ET、AngⅡ、IMT、斑块厚度和斑块长度均较治疗前下降(P<0.05),SBP、DBP、ET、AngⅡ、IMT、斑块厚度和斑块长度低于对照组(P<0.05);两组NO浓度均较治疗前上升,观察组高于对照组(P<0.05)。药物不良反应总发生率比较,无统计学差异(P>0.05)。结论西拉普利联合拉西地平能够有效控制高血压患者血压,调节血管活性物质表达,延缓颈动脉粥样硬化进展。

Effects of cilazapril combined with lacidipine on vasoactive substances and carotid atherosclerosis in patients with hypertension

Objective To discuss the Effects of cilazapril combined with lacidipine on vasoactive substances and carotid atherosclerosis in patients with hypertension.Methods The hypertensive patients(n=110)were randomly divided into the control group(n=53)and the observation group(n=57).The control group was treated with cilazapril,while the observation group was treated with lacidipine on the basis of the control group.The clinical efficacy and changes of blood pressure,vasoactive substances,carotid artery intima-media thickness(IMT),plaque thickness and plaque length were compared before and after treatment,and adverse reactions were recorded in 2 groups.Results The comparison in the total effective rate had no statistical significance between 2 groups(P>0.05).The comparison in systolic blood pressure(SBP),diastolic blood pressure(DBP),endothelin(ET),angiotensin II(Ang II),nitric oxide(NO),IMT and plaque thickness and plaque length had no statistical significance between 2 groups before treatment(P>0.05).After treatment,the levels of SBP,DBP,ET,AngⅡ,IMT,plaque thickness and plaque length had decreased in 2 groups(P<0.05),but the comparison in had no statistical difference between 2 groups(P>0.05).The SBP,DBP ET,AngⅡ,IMT,plaque thickness and plaque length were lower in the observation group than those in the control group(P<0.05).The level of NO increased in 2 groups after treatment had increased in the observation group than that in the control group(P<0.05).The comparison in the total incidence rate of adverse reactions had no statistical difference between 2 groups(P>0.05).Conclusion Cilapril combined with lacidipine can effectively control the blood pressure of hypertension patients,regulate the expression of vasoactive substances and delay the progression of carotid atherosclerosis.