间苯三酚用于促进产程进展的疗效及安全性分析

目的：分析间苯三酚用于促进产程进展的疗效及安全性。方法：选择产科分娩的足月妊娠初产妇76例，分为观察组和对照组，两组产妇进入潜伏期后以催产素2．5U加入5％的葡萄糖500ml静脉滴注，根据宫缩强度调节滴速。观察组产妇在出现规则宫缩且中等强度时予以间苯三酚80mg静脉注射；对照组产妇不使用间苯三酚。结果：观察组产妇的潜伏期和活跃期均明显短于对照组（P〈0．05）。两组产妇第二和第三产程时间比较无明显统计学差异（P〉0．05）。观察组产妇剖宫产4例，对照组产妇剖宫产13例，观察组产妇的剖宫产率明显低于对照组（χ2=6．77，P〈0．01）。观察组产妇的宫颈水肿的发生率明显低于对照组（χ2=5．65，P〈0．05）。两组产妇软产道裂伤、产后24h出血量和新生儿Apgar评分比较无明显统计学差异（P〉0．05）。结论：间苯三酚应用于产妇自然分娩中可明显缩短总产程时间，降低了剖宫产率，促进了宫颈软化和扩张，减轻宫颈水肿，不增加软产道裂伤、产后出血量和新生儿窒息率，安全性较好。

Effect and safety of phloroglucinol on labour progression

Objectives： To explore the curative effect and safety of phloroglucinol on labour progression. Method： Seventy - six primipara cases with normal term pregnancy and vaginal delivery were randomly divided into the observation groups and the control group. All the puerperas got intravenous drip of 500ml of 5% glucose solution added with 2.5U oxytocin at the beginning of latent phase of labor, and the speed was regulated by uterine contraction length. Puerperas of observing group got intravenous injection of phloroglucinol 80mg at the beginning of regular and moderate strength contraction, but puerparas of control group did not. Results ： the latent and active phase of the observation group were significantly shorter than that of thecontrol group （ P 〈 0. 05 ）. There was no significant difference in the second or third stage of labor between the two groups （ P 〈 0. 05 ）. The cesarean section rate of the pbservation group （4 cases） was significantly lower than that of the control group （ 13 cases） （χ2 = 6. 77, P 〈 0. 01 ）. The occurrence rate of cervical edema of observing group was significantly lower than that of thecontrol group（χ2 = 5.65, P 〈 0. 05）. There was no difference of injuries in the soft birth canal, the amount of 24h postpartum bleeding and newborn＇ s Apgar score between the two groups （P 〉 0. 05 ）. Conclusion： Using phloroglucinol during vaginal delivery can obviously shorten the total stage of labor, reduce the cesarean section rate, promote the softening and extending of the cervix, alleviate the cervical edema, and produce little injuries of soft birth canal, less amount of postpartum bleeding and neonatal asphyxia.