血清脂联素水平与冠心病患者冠脉病变稳定性及狭窄程度的相关性分析

目的探讨血清脂联素水平与冠心病患者冠脉癌变稳定性及病变程度的关系及其可能的作用机制。方法选择164例冠心病患者．分为稳定型心绞痛组和不稳定型心绞痛组，所有患者均行经皮冠脉造影，根据冠脉造影结果进行冠脉挟窄程度的Genisi记分评估，用双抗体夹心ELISA法检测。按两组患者血清脂联素的水平，观察血清脂联素水平与冠心病患者冠脉病变稳定性及狭窄程度的关系。结果稳定型心绞痛组患者血清脂联素水平高于不稳定型心绞痛组患者（7．01mg／L±2．61mg／Lvs4．59mg／L±2．26mg／L，P〈0．05）；经过Logistic回归分析和多元逐步回归分析，血清脂联素水平对冠脉病变的不稳定型和冠脉的狭窄程度具有独立预测价值。结论脂联素对冠脉粥样硬化具有保护作用，血清脂联素水平与冠脉病变的不稳定性和冠脉的狭窄程度具有一定的相关性。

The Relationship between Serum Adiponectin and Stability of Lesions and Severity of Coronary Stenosis Patients with in Disease Coronary Heart

Objective To investigate the relationship between serum adiponectin （APN） and stability ot lesions and severity ol coronary stenosis in patients（pts） with coronary heart disease（CHD）. Methods One hundred and four pts with CHD after coronary angiogra- phy （CAG） were enrolled and divided into stable angina pectoris （SAP group） and unstable angina pectoris（UAP group）. The serum APN levels were examined by enzyme - linked immunosorbent assay（ELISA）. The severity of coronary stenosis was evaluated by Genisi coronary score system. Results The serum APN levels in SAP group were higher than that in UAP group （7.01 mg/L±2.61 mg/L vs 4.89 mg/L±2.26 mg/L,P〈0.05）. Multiple logistic analyses showed that the level of serum APN were the independent predictors of stability of lesions and severity of coronary stenosis. Conclusion APN might be a valuable strategy to protect pts from CHD. The serum APN levels might be related with stability of lesions and severity of coronary stenosis.