| 血浆白细胞介素6和10水平与不同类型淋巴瘤的关系及其临床意义 |
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| 作者姓名： | Wang X Zhao HR Gu X Liu P Bikmituofu H |
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| 作者单位： | 1. 新疆医科大学第一附属医院 病理科,新疆乌鲁木齐,830054
2. 新疆医科大学第一附属医院 肿瘤中心,新疆乌鲁木齐,830054 |
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| 基金项目： | 国家自然科学基金(30860096)~~ |
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| 摘 要： | 目的探讨不同类型淋巴瘤血浆白细胞介素6(IL-6)和10(IL-10)的表达以及与临床特征、治疗反应、预后指标的关系。方法采用酶联免疫吸附(ELISA)法测定132例恶性淋巴瘤患者及132例健康对照者血浆IL-6和IL-10浓度。结果不同类型淋巴瘤患者血浆IL-6和IL-10水平均高于健康对照组(P<0.05),不同类型比较除T-NHL组血浆IL-6水平高于B-NHL,差异有统计学意义(P<0.05),其余组间差异皆无统计学意义(P>0.05)。哈萨克族患者IL-6水平高于汉族和维吾尔族;有B症状、IPI高危组、β2-MG、LDH和CRP高水平组血浆IL-6水平高于无B症状、低危组、β2-MG、LDH和CRP低水A平r组bo,r差分异期有Ⅰ统～Ⅱ计、学无意B义症(状P、<β02.-0M5)G。和ACnnR APr低bo水r分平期组Ⅲ,差～Ⅳ异、有有统B计症学状意、β义2-(MPG<和0.0C5)R。P高化水疗平后(C组R)患血者浆IILL--61和0水IL平-1高0水于平An明n显低于PR、PD和未治疗组(P<0.05);血浆IL-10和IL-6及IL-10和β2-MG呈正相关(P<0.05)。结论淋巴瘤患者IL-6和IL-10水平明显高于健康对照组,其水平的高低与肿瘤负荷有关;检测血浆中IL-6和IL-10的水平,可以做为临床淋巴瘤诊断、判断疗效和预后的辅助指标。
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| 关 键 词： | 白细胞介素6 白细胞介素10 淋巴瘤 酶联免疫吸附法 |
Plasma interleukin-6 and interleukin-10 levels in different subtypes of lymphoma and their clinical significance |
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| Wang X,Zhao HR,Gu X,Liu P,Bikmituofu H.Plasma interleukin-6 and interleukin-10 levels in different subtypes of lymphoma and their clinical significance[J].Journal of Southern Medical University,2011,31(8):1360-1364. |
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| Authors: | Wang Xin Zhao Hua-rong Gu Xia Liu Pan Bikmituofu Hadeti |
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| Affiliation: | WANG Xin1,ZHAO Hua-rong2,GU Xia1,LIU Pan2,Hadeti Bikmituofu1 1Department of Pathologys,2Department of Oncology,First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China |
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| Abstract: | Objective To study the plasma levels of interleukin6(IL-6) and interleukin10(IL-10) in patients with lymphoma and their association with the clinical characteristics and prognosis.Methods The plasma levels of IL-6 and IL-10 were measured in 132 lymphoma patients and 132 healthy controls using enzyme-linked immunosorbent assay(ELISA).Results The levels of plasma IL-6 and IL-10 in lymphoma patients were significantly higher than those in healthy controls(P<0.05).The plasm a levels of IL-6 were significant hig... |
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| Keywords: | interleukin-6 interleukin-10 lymphoma enzyme-linked immunosorbent assay |
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