Rb基因产物与胆囊癌生物学特性的关系

目的 探讨Ｒｂ蛋白与胆囊癌的肿瘤生物学行为的关系。方法 采用免疫组化ＳＰ染色方法检测４１例胆囊癌、７例胆囊腺癌及１４例胆囊炎石蜡标本Ｒｂ蛋白表达水平。结果 Ｒｂ蛋白表达阳性率在胆囊癌组为５８．７％，明显低于胆囊炎（１００％）及胆囊腺瘤组（１００％）；且低分化癌组与高、中分化癌组，Ｓ４、Ｓ５期与Ｓ１、Ｓ２、及Ｓ３期比较均有显著性差异（Ｐ〈０．０５）。结论 Ｒｂ蛋白表达与胆囊癌的分化程度、浸润深度及预

THE RELATION BETWEEN RETINOBLASTOMA GENE EXPRESSION AND BIOLOGICAL CHARACTERISTICS OF GALLBLADDER CARCINOMA

Objective To study the relation between retinoblastoma (Rb) gene expression and biological characteristics of gallbladder carcinoma. Methods The expression of Rb protein in tissues of 41 cases of gallbladder carcinoma, 7 cases of gallbladder papilloma, and 14 cases of cholecystitis were detected by immunohistochemical staining of SP with polyclonal antibody. Results The rate of positive staining was 58.7% in gallbladder carcinoma which was significantly lower than that in cholecystitis and gallbladder papilloma (100%). There was a significant difference of Rb protein expression among the low, moderate and high differentiations and so was between S 5, S 4, S 1, S 2 and S 3 stage ( P <0.05). Conclusion It sugests that expression or non expression of Rb gene is closely related to the malignant potential invasiveness and prognosis of gallbladder carcinoma.